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Lack of pleasure is the core symptom of depression, which can be divided into physical pleasure loss and social pleasure loss, the former manifested as the loss of pleasant sensations of individual physical stimulation (food, smell, touch, etc.1
Leptin enhances social location preference
In the two boxes of devices that can be freely passed, a new nest is placed on each side, and the pre-experimental puberty (6 weeks old) mice can freely shuttle in the two new nest environments, and then multiple mice are placed on the side of the A new nest, and the mice are grouped for 24 mice, and then the mice live alone on the side of the B new nest for 24 hours, and it is found that both female and male mice are willing to stay on the side of the A new litter, and there is a clear social position preference, but this position preference can be destroyedby chronic stress.
Figure 1: Social preference in adolescent mice
2
Leptin promotes social isolation aversion, rather than social rewards, related to motivated behavior
The above social position preferences involve two different motivational processes: social activity preferences (social living) and social isolation aversion (living alone).
Figure 2: Leptin-driven social isolation-related aversion behavioral motivation
3
Oxytocin in the brain is a downstream target of leptin
Oxytocin in the hypothalamic paraventricular nucleus (PVN) plays a key role
in regulating social behavior.
Figure 3: Hypothalamic leptin receptor and oxytocin expression
summary
In this paper, we established social conditioned position preferences in adolescence through behavior, and found that leptin can promote conditional position preferences by enhancing motivational behaviors related to social distancing, and can effectively alleviate the lack of
social pleasure caused by adolescent stress.
【References】
1.
The images in the article are from references
