Tianjin University has developed "cluster enzymes" to bring good news to patients with neuroinstration

News Agency, Tianjin, January 11 (Zhang Jianxin, Jia Defang) Recently, the Tianjin University Medical Department Zhang Xiaodong team successfully designed a new type of artificial enzyme - "cluster enzyme." "Cluster enzyme" has super catalytic activity and selectivity, the treatment of Alzheimer's disease, brain injury and other neuro-inflammation has great potential, the results have been published online in the international authoritative journal Nature Newsletter.
is an important catalyst in the organism, and it is a catalytic organic matter produced by living cells. Enzyme catalysis can increase the speed of chemical reaction by more than a hundred times at room temperature and pressure, and has great application value in the field of medicine for neurology, tumor, bioresortics, etc., and is also widely used in agriculture, food, chemical industry and other fields. However, most natural enzyme preparation difficulties, poor stability, harsh catalytic conditions, difficult to large-scale application. How to design artificial enzymes with high catalytic activity and selectability has become a common problem for scientists around the world.
Xiaodong team from Tianjin University's Department of Medicine put forward the concept of "cluster enzyme", which they successfully designed by means of single-atom regulation of a class of artificial enzymes with the precise structure of atoms - "cluster enzymes". Experiments show that "cluster enzyme" has high catalytic activity and selectivity, and its antioxidant activity is 160 times that of natural water-soluble vitamin E and 9 times that of anthratin molecules. Biological results show that the use of "cluster enzyme" agent can effectively reduce nerve inflammation in brain-damaged mice, significantly reducing the inflammatory factors in mice. In particular, the "cluster enzyme" size is very small, can be naturally filtered through the kidneys, which also means that the use of "cluster enzyme" drugs can avoid damage to organs such as liver and kidneys.
" cluster enzyme" has broad application prospects in biomedical science, especially in neuroscience and engineering. Zhang Xiaodong, head of the team, said, "Next, we will continue to improve the variability of the cluster enzyme, improve its targeting function, and tap into its potential for the treatment of Alzheimer's disease, brain damage and other major neuroinflamms." ”