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Tianjin Gongsheng Institute makes progress in genome diversity editing of Saccharomyces cerevisiae

 Last Update: 2022-05-08
 Source: Internet
 Author: User

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As one of the important chassis cells of synthetic biology, Saccharomyces cerevisiae can be used to develop traditional brewed foods, bulk chemicals and high value-added products

Recently, the evolution and metabolic engineering research team led by Wang Qinhong, a researcher at the Tianjin Institute of Industrial Biotechnology , Chinese Academy of Sciences , based on the design and modification of the endogenous double-strand break (DNA double-strand break, DSB) repair pathway of Saccharomyces cerevisiae and CRISPR genome editing, established A highly efficient template-independent mutagenic genome editing (mGE) technology has been developed, and the heritable diversity of targeted genes can be regulated in expression .

The related research results were published in Microbiology Spectrum

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