Thyroid: Metabolic Syndrome and Risk of Thyroid Cancer

The relationship between metabolic syndrome and its components and the risk of thyroid cancer is not clearIn a recent study published in the authoritative journal Thyroid, researchers conducted a large-scale, nationwide, population-based cohort study to explore the associationThe researchers analyzed 9890917 adults without thyroid cancer in the National Health Insurance Health Check database between January 1 and December 31, 2009The subjects had at least three of the five components of metabolic syndrome: abdominal obesity, hypertriglyceride, low HDL cholesterol, high blood pressure, and high blood sugarThe multivariate Cox proportional risk model is used to assess the risk of thyroid cancerDuring an average of 7.2 years of follow-up, researchers found 77,133 new cases of thyroid cancerThe risk of thyroid cancer in patients with metabolic syndrome was higher than in patients with non-metabolic syndrome (1.15 HR; 95% CI was 1.13-1.17)In the obesity group (HR 1.10, 95% CI was 1.07-1.13), there was a significant correlation between metabolic syndrome and thyroid cancer risk, while the non-obesity group (HR 1.002, 95% CI was 0.98-1.03) was not statistically significantThe effect of metabolic syndrome on thyroid cancer risk varies from obesity to obesity (interaction P-0.017)Subjects with all five components of metabolic syndrome had a 39 percent higher risk of thyroid cancer than those without any component (HR was 1.39; 95% CI was 1.33-1.44)Subjects in the obesity group (HR 1.29; 95% CI 1.21-1.38) had a higher risk of thyroid cancer in all five groups, while the non-obese group had a higher risk of thyroid cancer (HR was 1.06; 95% CI was 0.98-1.14)There was a significant interaction between the number of metabolic syndrome components and obesity (interaction P 0.001)Because of the combined effect of obesity and metabolic syndrome on thyroid cancer risk, obese men with metabolic syndrome had the highest risk of thyroid cancer (HR 1.58, 95% CI 1.52-1.64) compared to men without metabolic syndrome, but not in obese women with metabolic syndromeIt can be seen that metabolic syndrome is associated with an increased risk of thyroid cancer in the general populationIn obese people, the risk of metabolic syndrome and thyroid cancer is more pronouncedIn men, metabolic syndrome and obesity are associated with a higher risk of thyroid cancer, but not in women