This article takes you to understand chloral hydrate

· 【Product Name】Chloral hydrate · 【Specification】500g · 【Formulation】: Chemical API · 【Properties】This product is white or colorless transparent crystal; it has a pungent odor and gradually volatilizes in the air
.

· 【Manufacturer】Qingdao Yulong Seaweed Co.
, Ltd.
· 【Approval No.
】Guoyao Zhunzi H37022673 Qingdao Yulong Seaweed Chloral Hydrate API Origin Wholesale Price · 【Functions/Indications】1.
Treat insomnia, suitable for falling asleep difficult patients
.

As a hypnotic drug, it is effective for short-term use, but ineffective for continuous use for more than two weeks
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2.
Medication before anesthesia, surgery and sleep EEG can calm and relieve anxiety, making the corresponding treatment process safer and more stable
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3.
Anticonvulsant, used for the treatment of status epilepticus, also can be used for the convulsions caused by high fever, tetanus and feline in children
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[Usage and Dosage] The usual dose for adults: hypnosis, oral or enema 0.
5~1.
0g, once before going to bed, orally should be prepared into a 10% solution or mucilage for use, and the 10% solution should be diluted 1~2 times for enema pour
in.

· Sedation: 0.
25g once, 3 times a day, after meals
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· For status epilepticus, 20~30ml of 10% solution is commonly used, diluted 1~2 times and then poured into it at one time, and the effect can be seen
.

The maximum X amount is 2g at a time
.

Common dosage for children: hypnosis, one time according to body weight 50mg/kg or 1.
5g/m2 of body surface area, take it before going to bed, the maximum X amount at a time is 1g; it can also be 16.
7mg/kg body weight or 500mg/m2 according to body surface area, daily 3 times
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· For sedation, take 8 mg/kg of body weight or 250 mg/m2 of body surface area at a time, the maximum X amount is 500 mg, 3 times a day, after meals
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Enema, each time according to body weight 25mg/kg
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The maximum amount is 1g each time
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· 【Adverse reactions】· 1.
It is irritating to the gastric mucosa, which is easy to cause E heart and vomiting
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2.
Large doses can inhibit myocardial contractility, shorten myocardial refractory period, and inhibit the respiratory and vascular motor centers of the medulla oblongata
.

3.
Harmful to the liver and kidneys
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4.
Occasionally allergic rash, urticaria
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5.
Long-term use can cause dependence and tolerance.
Abrupt withdrawal can cause severe withdrawal syndromes such as nervousness, hallucinations, irritability, abnormal excitement, delirium, and tremor
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· 【Contraindications】 · Contraindicated in patients with severe impairment of liver, kidney and heart function
.

Contraindicated in patients with intermittent hematoporphyria
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· 【Drug Interactions】· (1) When the central nervous system depressant, central depressant antihypertensive drug and this product are used in combination, the central inhibitory effect of chloral hydrate can be more obvious
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(2) When used together with anticoagulant drugs, the anticoagulant effect is weakened, and the prothrombin time should be measured regularly to determine the amount of anticoagulant drugs
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(3) Intravenous injection of furosemide injection after taking chloral hydrate can cause sweating, fever, and increase in blood pressure
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Chloral hydrate CAS: 302-17-0 Anticonvulsant API Instructions How to prepare 5% and 10% chloral hydrate solutions for hospital use? · Precautions for the preparation and use of chloral hydrate solution · Chloral hydrate is mainly used for sedation and hypnosis in children, for sedation and hypnosis before anesthesia, surgery and various examinations
.

· The chloral hydrate generally used in hospitals is 5% and 10% chloral hydrate solutions
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1.
Preparation of chloral hydrate solution: Instrument: medicine balance, measuring cup, glass rod, beaker Reagent: chloral hydrate, sterile water Operation method (take 250ml of 10% chloral hydrate solution as an example): weigh Chloral hydrate 25g, add an appropriate amount of water to dissolve, after the chloral hydrate is completely dissolved, add water to the mark
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· 2.
Precautions for preparation: · (1) The measuring cup and glass rod should be rinsed with sterilized water before use; · (2) The capacity of the 250ml measuring cup and the reagent bottle containing chloral hydrate solution is inconsistent, and the scale line of the measuring cup shall prevail to ensure that The liquid concave surface is tangent to the engraved line; 3.
Precautions for use: (1) The shelf life of the prepared chloral hydrate solution is three months: (2) The prepared chloral hydrate solution can be slowly decomposed into Hydrochloric acid, trichloroacetic acid, and dichloroacetaldehyde decompose very quickly under heating and ultraviolet light irradiation, so they should be protected from light during storage and stored in a cool place: Store in large quantities and seal after use
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· Chloral hydrate enema is mainly used for children with febrile convulsions or epilepsy, which can play anticonvulsant and stop convulsions; because the baby does not cooperate with some auxiliary examinations, the baby moves back and forth, and the crying affects the examination effect, especially the echocardiography, ct, or angiography, abdominal color ultrasound, etc.
, orally taken half an hour before the examination, it can play a sedative and hypnotic effect.
Generally, it is calculated as 25㎎ of chloral hydrate per kilogram of body weight.
If it is a prepared 10% chloral hydrate solution , calculated according to 1ml per kilogram of body weight, there is no side effect on the baby
.

However, the individual differences of the baby are relatively large, and the doctor or nurse will adjust the dose to the baby according to the specific situation of the baby
.