These new tools will significantly increase drug delivery to tumors

July 10, 2019 / bioin / - cancer treatment is complicated by its microenvironment and vascular abnormalities that maintain the tumor The European Union funded neonano project has developed ways to improve the delivery of cancer drugs and improve the effectiveness of cancer treatment It's difficult to give drugs to tumors They rely on abnormal vascular structure, uneven distribution and relatively poor blood flow, so the delivery of drugs is very challenging Once the drug is delivered, the dense and hostile tumor microenvironment makes it difficult to precisely locate the drug Photo source: http://cn.bing.com neonano (a new auxiliary nanodrug for vascular normalization) project aims to determine whether the pretreatment of tumor with anti-inflammatory nanodrugs can improve the delivery of drugs to the areas most in need of drugs The project assesses the potential of using anti-inflammatory nanodrugs to pretreat tumors, preparing the tumor vascular system for more effective drug and oxygen delivery, thereby improving the efficacy of subsequent chemotherapy and radiotherapy The researchers evaluated drugs (liposome dexamethasone, anti CCL2 preparation, macrophage regulatory protein) and physical combination therapy (ultrasound) to improve delivery and efficacy of standard chemotherapy drugs (< 1 nm) and nanodrug preparations (10-100 nm) "The first step in building a more effective way to treat cancer is to understand the structure of the tumor," explains professor TWan Lammers, lead researcher of the project Then, we need to accurately visualize and quantify the drug delivery in the structure "In the first half of the project, neonano optimized in vivo and in vitro contrast-enhanced computed tomography (CT) to improve the quantitative three-dimensional analysis of tumor vascular networks To determine the distribution of the drug and to see if there is any accumulation in the tumor, the team also used a hybrid computed tomography (ct-fmt) This enables them to make noninvasive and quantitative assessments of the biological distribution and target accumulation of nanopharmaceutical preparations Using these visualizations, neonano continues to assess the impact of vascular normalization on tumor blood vessels, on tumor drug delivery, and the efficacy of nanodrug based combination therapy Photo source: http://cn.bing.com improve the efficiency of drug delivery system "We found that by using dexamethasone liposome, we can reduce the collagen content in tumors "It helps with the accumulation and penetration of drugs," said Professor Lammers of the University of Aachen in Germany The study of this project shows that the drug delivery system (DDS) also benefits from the inhibition of CCL2 dependent macrophage infiltration and has the additional advantage of weakening pathological angiogenesis Finally, the project shows that it is possible to open blood vessels in tumors and brain through the combination of ultrasound and microbubbles, so as to enhance the extravasation and infiltration of DDS These findings provide clinicians with new tools to treat tumors, making them more susceptible to traditional chemotherapy and radiotherapy Their results show that drug delivery and physical activation, such as the widely applicable ultrasound protocol, can improve the delivery of tumor targeted drugs Photo source: http://cn.bing.com Aachen multiple myeloma clinical and Transformation Research Center is currently conducting the first human clinical trial evaluation of dexamethasone liposome "The EU funding we have received through neonano has contributed to the development of targeted combination therapies for cancer," Lammers said Through neonano, we have taken relevant measures to further develop a new liposome corticosteroid preparation, which may have multiple advantages when combined with other drugs in patients with multiple myeloma "Reference materials: [1] new tools to boost the delivery of drugs to cancer tubes [2] microbubbles open brain's barrier to make chemo more effective [3] drug delivery to brain tumors [4] Takahiro Seki et al Enhanced delivery of macroeconomic antitumor drugs to tutorials by nitroglycerin application Cancer science DOI：https：//doi.org/10.1111/j.1349-7006.2009.01323.x 【5】Minchinton A I， Tannock I F Drug penetration in solid tumours [J] Nature Reviews Cancer， 2006， 6(8)： 583 【6】Madani S Y， Naderi N， Dissanayake O， et al A new era of cancer treatment： carbon nanotubes as drug delivery tools[ J] International journal of nanomedicine， 2011， 6： 2963.