These have to be seen about the latest research progress of the heart

May 15, 2019 / BIOON / - from the moment of birth, our heart will beat differently, pumping blood to the whole body, providing nutrition and oxygen for all organs and tissues of the whole body, taking away waste and carbon dioxide until the end of our lives So the heart is vital to our lives Such an important organ, of course, will attract a large number of scientists to carry out research on it Therefore, in this article, I reviewed the latest research progress on the heart for you, in order to increase your understanding of the heart Photo source: www.pixabay.com [1] JCI insights: how the heart talks with fat cells doi: 10.1172/jci.insight.123848 just like sending text by email or through cellular network, the heart can generate long-distance information across the body A new study by scientists at Lewis Katz School of medicine at Temple University (lksom) shows that this information eventually spreads to fat cells "People suspect the heart's ability to communicate directly with fat, but our study is the first to provide evidence of crosstalk between the heart and fat tissue, which is regulated by enzymes, G-protein-coupled receptor kinase 2 (GRK2)," the results of this study may have an impact on regulating weight gain in patients with heart failure, a condition in which the heart can no longer pump blood effectively into the body It will appear A breakthrough paper published online by Dr Koch and his colleagues in the journal JCI insight on May 16 showed that the heart relies on the heart specific messenger, the signaling enzyme GRK2, to transmit information about metabolism to fat cells The researchers studied mice in which GRK2 activity was inhibited When fed a high-fat diet, mice with GRK2 inhibition accumulated significantly more fat than those with normal GRK2 expression This experiment was repeated in mice with overexpression of GRK2 in the heart to simulate the increase of GRK2 in human heart failure When given a high-fat diet, the mice lost weight compared to their normal litters Using complex metabonomics, a method of studying metabolites associated with cellular processes, Dr Koch's team found that GRK2 signaling specifically alters the metabolism of branched chain amino acids (BCAA) and endogenous cannabinoids in the heart Mice overexpressing GRK2 on a high-fat diet had different metabolite profiles than those inhibited by GRK2 and normal mice 【2】 SCI signal: want to have a healthy heart? Two special proteins are essential! Doi: 10.1126/scientific.aau9685 recently, an international journal Science In the Research Report on signaling, scientists from institutes such as the National Institutes of health found that two proteins bound to stress hormones can cooperate with each other to maintain the health of the heart, both of which are stress hormone receptors, namely, glucocorticoid receptor (GR) and salt glucocorticoid receptor (MR), which can coordinate actions to protect the heart Keep the heart healthy When the signal between the two receptors is out of balance, it will cause heart disease in mice In this study, the researchers tested GR deficient mice in the laboratory, which spontaneously dilated their hearts, leading to heart failure and death When the researchers created Mr deficient mice, they found that the mice showed normal cardiac function The researchers wanted to know what would happen if both receptors were missing from the heart tissue, so they created mice that lacked GR and Mr they speculated that the mice with this double mutation would have the same or more serious heart problems as the mice without gr Photo source: http://cn.bing.com What's surprising is that the heart of this double mutant mouse is resistant to heart disease, so why does this mouse protect itself against heart disease? The researchers found that these double mutant mice do not have gene changes that cause heart failure (the same as the mice without GR), but also show the basis for protecting the heart Due to function, although the hearts of these mice were normal, their hearts showed slightly dilated characteristics compared with those of mice without Mr Finally, the researchers speculate that GR and MR will work together to maintain heart health, so in the later stage, we will further study and develop new drugs to play a role on these two receptors at the same time, so as to effectively help improve the heart function of patients with heart disease and effectively prevent the possibility of heart attack in the later stage 【3】 Commun Biol: a study led by researchers from Queen Mary University in London found that the association between shorter stature and higher risk of heart disease is mainly due to our lungs In the study, published in the journal communications biology, the researchers examined more than 800 loci in the human genome known to be associated with adult height, and evaluated data showing that lower height increases the risk of type 2 diabetes and coronary heart disease The authors found that once an individual's BMI was taken into account, there was no causal relationship between hypertension and the risk of type 2 diabetes, but there was a significant causal relationship between height and the risk of heart disease The study looked at a number of traditional heart disease risk factors, including cholesterol, triglycerides, blood pressure, percentage of fat and socio-economic parameters, including education and income, but found that they accounted for only a small proportion of the high impact on the heart Our lung function accounts for most of this effect Professor Panos deloukas, from Queen Mary University in London, said: "shorter individuals can consider regular exercise and avoid sedentary lifestyle and quit smoking habits to reduce the risk of heart disease As shown in the sample study, the impact of shorter height on heart disease risk is mediated by lung function "Our findings and further studies of this nature contribute to a healthy lifestyle, especially physical activity that improves lung function." 【4】 JACC: make it worse! Lung disease significantly increases the risk of heart disease doi: 10.1016/j.jacc.2018.11.063 a new study shows that people with some common lung diseases have a higher risk of heart disease and other major heart problems The team of Cardiology and lung health doctors from University of Manchester and Aston University School of Medicine found that patients with asthma, chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis were more likely to suffer from heart disease and heart failure The study involved 100000 patients with lung disease in northwest England and was followed up for 14 years The related research results were recently published in Journal of the American College of Cardiology These increased risks do not include other risks such as diabetes and high blood pressure Photo source: http://cn.bing.com despite this association, researchers found that patients with lung disease were less likely to undergo bypass or angioplasty "The most surprising finding was a 50%, 60% and 70% increase in the risk of coronary heart disease in patients with asthma, pulmonary fibrosis and COPD," said Paul Carter, PhD, lead author of the study and member of the acalm team at Aston medical school In addition, the risk of heart failure doubled in patients with COPD " Dr Rahul potluri, head of the acalm research group at Aston medical school, said: "although patients with lung disease have an increased risk of heart disease, they are less likely to be treated for heart disease Possible causes include difficulty in diagnosis due to similar symptoms, and a higher risk of complications in patients with lung disease receiving heart disease treatment Of course, more work is needed to investigate the phenomenon in more detail and find solutions " 【5】 J aging health: the more children you raise, the higher your parents' risk of heart disease doi: 10.1177/0898264319831512 according to a new finding of public health experts from Myron B Thompson School of social work, University of Hawaii, parents with five or more children are at a higher risk of heart disease than parents with only one or two children The study, led by Sara HIPP, a recent Ph.D graduate from the office of public health research projects, analyzed data from about 25000 participants aged 50 or older The results were published in Journal of aging and health HIPP and colleagues found that 30% of parents with five or more children had heart disease, such as coronary heart disease, angina or congestive heart failure The proportion of parents with one or two children was only 22%, compared with 21% of parents without children One in four of the participants said they had been told by a doctor that they had heart disease in the past two years "Our data shows that the more children there are, the higher the risk of heart disease, for both men and women." HIPP said The trend remained when researchers adjusted for other factors that might affect heart disease "This study is important because it's a large, comprehensive analysis that not only demonstrates the results of several small studies in the past, but also new findings that have found a relationship between male child rearing and heart disease." Yan Yan Wu, assistant professor of Biostatistics at the school of public health 【6】 Science: accident! Thyroid hormone makes us lose the ability of heart regeneration doi: 10.1126/science.aar2038 Although in 735000 heart attacks every year in the United States, most patients survive, but unlike many other cells in the body, once the heart cells are damaged, they cannot regenerate In a new study, researchers from the United States, Australia and France found that this problem can be traced back to our earliest mammalian ancestors, who may have lost the ability to regenerate heart tissue in exchange for a warm blood state This is a Faustian evolutionary trade, which ushered in the mammalian era, But it makes modern people vulnerable to irreparable tissue damage after a heart attack Relevant research results were published online in the Journal of science on March 7, 2019, with the title of "evidence for hormonal control of heart regulatory capacity during other acquisition" The thyroid produces a pair of well studied hormones known to regulate body temperature, metabolic rate and normal heart function Since these hormones play a key role in promoting heat production to maintain body temperature, they are believed to be the driving force behind the evolutionary transition from cold blood to warm blood But the new study shows that these hormones also help shut down the division of heart cells, thereby preventing the heart tissue from repairing itself after being damaged This finding is the first to confirm the association between thyroid hormones, heart development and repair, and warm blood evolution Using a multi species approach, Huang's team compared the "ploidy" - the number of copies of each pair of chromosomes in the heart cells of 41 different vertebrate species Ploidy is closely related to the ability of cell division and replication In fact, all the animal cells that are actively dividing are diploid There is only one pair of chromosomes in each pair In each pair of chromosomes, one