There is increasing evidence that enteroviruses are responsible for acute powerless myelitis

October 27, 2019 / Biovalley BIOON / - -- evidence published by a group of researchers suggests that enteroviruses are the culprit of a mysterious neurological disease that has paralyzed nearly 600 children in the United States in the past few years This study was reported on the biorxiv preprint server in June 2019, and described in the journal Nature Medicine on October 21, 2019 Nearly 70% of acute flaccid myelitis was found, AFM, also known as acute tardive myelitis), has enterovirus specific antibodies in the spinal fluid of children, compared with only 7% of children who do not have the disease Ev-d68 virus particles, picture from Wikimedia / Cynthia S Goldsmith and Yiting Zhang, CDC "The advantage of this study is not only what it finds, but also what it doesn't," said Joe DeRisi, co-author of the paper at the University of California, San Francisco Enterovirus antibody is the only antibody rich in AFM patients No other virus family showed elevated antibody levels " AFM was first found in 2012 Although it is still rare, it has been on the rise in recent years among American children Over 500 children have been diagnosed with AFM in the past five years These cases are similar to those typical of enterovirus infection, namely, the high incidence rate and low incidence rate alternated from one year to the next In the United States, there were 22 AFMS in 2015, 149 in 2016, 35 in 2017 and 232 in 2018 The disease attacks the gray matter in the spinal cord of children, eventually leading to long-term disability, a symptom comparable to polio, which itself is caused by enteroviruses Although previous studies have pointed out the role of enteroviruses (especially ev-d68 and ev-a71 strains) in AFM pathology, doctors are not always able to identify these viruses in spinal fluid As a result, the researchers developed a tool to scan patients' spinal fluid for antibodies to hundreds of different viruses, including enteroviruses, herpetic, Zika, and measles intestines, to identify which viruses are present or recent, and which are not They found that more than two-thirds of 42 children with AFM had antibodies against enteroviruses (but no antibodies against other types of viruses), compared with just one in ten of 58 children who did not have the disease This result is supported by similar findings from another small study on enterovirus antibodies published in the Journal mbio in August 2019 Raina MacIntyre, an epidemiologist at the University of New South Wales in Australia, told science that "I think it's time to stop arguing about whether enteroviruses cause AFM, which is very strong evidence." These findings may help scientists begin to develop a vaccine for the treatment of AFM, but questions remain about how the disease is linked to enteroviruses Enterovirus infection is very common It is not clear why only some infected children will continue to develop AFM, or why the disease is becoming more and more common (BIOON Com) reference: 1 Ryan D Schubert et al Biological and metrological interaction of cerebellar fluid impacts environments in pediatric Institute flaccid myelitis Biorxiv, 2019, doi:10.1101/666230 2.Ryan D Schubert et al Pan-viral serology implicates enteroviruses in acute flaccid myelitis Nature Medicine, 2019, doi:10.1038/s41591-019-0613-1 3.‘Missing’ Virus Detected in Dozens of Children Paralyzed by Polio-Like Illness https:// 4.Nischay Mishra et al Antibodies to Enteroviruses in Cerebrospinal Fluid of Patients with Acute Flaccid Myelitis mBio, 2019, doi:10.1128/mBio.01903-19 5.Evidence links poliolike disease in children to a common type of virus https:// 6.More Evidence that Enterovirus May Cause Kids’ Paralyzing Disease
Https:// 7.biorxiv: Enterovirus may be the main cause of acute powerless myelitis in children http:// 8.mbo: new research reveals the pathogenesis of acute tardive myelitis http://news.bioon.com/article/6736295.html