There is hope for the development of new antibiotics

Our reporter (Xiong Yan) learned from Kunming Institute of zoology, Chinese Academy of Sciences that the researchers studied the antibacterial peptide of king cobra venom, and found that the ability of clinical drug-resistant bacteria to its drug resistance was very low, and the effect was far beyond the traditional antibiotics This discovery is expected to solve the problem that the most troubled antibiotics are ineffective due to long-term use, and will have a positive impact on the development of new antibiotics Due to the extensive use and abuse of traditional antibiotics by modern people, a variety of drug-resistant strains have emerged in clinical practice, such as "superbacteria" carrying NDM-1 plasmid, methicillin resistant, vancomycin resistant pathogens, etc At present, antibiotics used in clinic have no effect on these resistant bacteria, and become a major threat to human health, especially in the future Therefore, natural antimicrobial peptides from all kinds of natural sources have become the hope of developing new antibiotics Under the support of the national 973 program, the joint fund of NSFC Yunnan Province and the key deployment project of the Chinese Academy of Sciences, the biotoxin and human disease research group of the Key Laboratory of animal model and human disease mechanism of Kunming Institute of zoology, Chinese Academy of Sciences, led by researcher Zhang Yun, Dr Li Sheng'an, etc., has done a lot of research work and related invention patents in the early stage The therapeutic effect of oh-cath30, an antibacterial peptide from king cobra venom, on keratitis caused by drug-resistant Pseudomonas aeruginosa was studied The researchers isolated 10 isolated strains of Pseudomonas aeruginosa from patients with keratitis, which are very sensitive to the antibacterial peptide oh-cath30 of king cobra venom, but not to the traditional antibiotics such as cefoperazone sodium, ciprofloxacin, gentamicin and levofloxacin, which are widely used in clinical medicine The results of animal model study showed that the clinical symptoms of keratitis caused by drug-resistant Pseudomonas aeruginosa could be significantly improved by using oh-cath30 alone or combined with levofloxacin In addition, the resistance of clinical resistant bacteria to oh-cath30 is very low The results of this study provide a pharmacodynamic basis for the development and clinical application of new anti drug resistant microbial infection drugs, the researchers said.