There is a new strategy for treating disc degenerative diseases in the vertebral disc

Not long ago, Shen Hongxing, director of spinal surgery at Renji Hospital, affiliated with Shanghai Jiaoda University School of Medicine, innovatively proposed "gene-hydrogel microencienties" in a study to provide a new treatment strategy for gene therapy for disc degeneration. The results paper was published as a cover article in the recent Advanced Science.
disc degression is the prerequisite and pathological basis for the development of a series of spinal delincation diseases, and is one of the most harmful and difficult diseases in spinal destasis diseases. In the process of disc degeneration, the decomposition/anabolic balance of the extrateribrate substitut is broken and the microenviron environment inside myelin nuclei deteriorates. Gene therapy can target the metabolic balance of extracellular substates by delivering synthetic miRNA to regulate gene expression levels, providing an ideal potential treatment for degenerative diseases.
However, in the process of delivering miRNA, there are shortcomings such as short half-life, easy degradation and low trans-contamination rate, while local injections are easy to cause leakage and leakage-related complications, resulting in the corresponding gene therapy can not be more widely and effectively applied.
To this end, the researchers by in-depth study of the pathogenesis of disc degeneration disease, combined with hydrogel load miRNA agonist Agomir to build a "gene-hydrogel microenvironment", the use of vertebral gap local injection, in-place targeted release of Agomir, reduce the expression of the substitut metal protease, regulate the intervertebral disc myelin nuclear cell external substate, especially type II collagen synthesis/decomposition metabolism balance, improve the tissue microenvironment, thereby inhibiting the development of the disease process.
Shen Hongxing, author of the paper, said that the proposal of "gene-hydrogel microencancer" not only provides a new way of thinking for the regeneration of the degenerative disc, but also provides a new theoretical basis and application platform for the treatment of various degenerative diseases, which has unique innovation and wide applicability. (Source: Huang Xin, China Science Journal)
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