There is a kind of cold called Grandma thinks you are cold. Research has revealed the reason why the older you are, the less resistant you are to freezing.

After the fall, when some young people continue to short-sleeved shorts, the elderly may be ready to put on sweaters

Recently, researchers from Yale University and the University of California, San Francisco (UCSF) have discovered one reason why the older the older the less frost-resistant

These immune cells are called type 2 innate immune cells (ILC2), and they are usually concentrated in areas that are prone to contact with pathogens, such as the nasal cavity, lungs, and skin

After further examination of mice of different ages, it was found that the number of ILC2 cells would decrease as the animals age

So, does it mean that promoting the body to produce more ILC2 cells can protect elderly animals from the cold and avoid illness? In order to supplement ILC2, the researchers first tried to supplement the animal with interleukin IL-33

However, the results of the experiment surprised the researchers

Through transcriptomics analysis, the researchers found that the remaining ILC2 in the fat of old mice has inherent defects in gene expression.

▲The innate immune cell ILC2 in adipose tissue changes with aging, which affects fat production and animal tolerance to cold (picture source: reference [1])

Therefore, the researchers switched to a method of extracting healthy ILC2 from young mice and transplanting them to old mice

The researchers pointed out that this result reminds those who want to manage to resist aging and want to restore youth, they need to pay attention to changes in the immune system

Note: The original text has been deleted

Reference materials:

[1] Emily L.

[2] Immune cell betrayal explains why it gets colder as we age.