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bacteria often exhibit strong biometric characteristics - some bacteria are abundant in specific locations, while others are not - leading to the main question when using microorganisms for treatment: How do bacteria get into the wrong place? How do we add the right bacteria to the right place when biometrics is "disordered"?
However, there is a big barrier to solving these problems, and the fact that bacteria are so small and numerous, with very diverse and complex populations, poses a major challenge in understanding which bacterial subsections live and what genes or metabolic abilities allow them to thrive in these "wrong" places.
recently, researchers at Harvard University and others, in a new study published in Genomic Biology, tested the human oral microbiome and found impressive variations in bacterial subgroups in certain areas of the mouth.
as microbial ecologists, we are fascinated by how bacteria divide any habitat into small habitats. Daniel R. Utter, one of the paper's authors and a doctoral candidate at Harvard University, said.
advances in sequencing and bio-informational methods provide new ways to reveal the complexity of bacterial community. Utter and Colleen Cavanaugh, Edward C. Jeffrey and others used these state-of-the-art sequencing and analysis methods to better understand oral microorganisms.
" mouth is the perfect place to study the microbiome. "It's not only the beginning of the gastrointestinal tract, it's a very special and small environment where there's enough microbe species to really start answering interesting questions about the microbiome and its evolution," said A. Murat Eren, an assistant professor in the Department of Medicine at the University of Chicago. The
searched a public database and downloaded 100 genomes representing four common bacteria in the mouth. With the help of new technology, researchers have found a large amount of variability. For example, in a microorganism, different genetic forms are highly relevant to a different part of the mouth. In many cases, the team was able to identify a small number of genes that might explain a particular habitat for a particular bacterial population. By applying metagroups, the researchers were also able to determine the specific difference between free bacteria in people's mouths and similar bacteria cultured in the laboratory.
and other similar studies could provide new insights into the role of oral microbes in human health.
relevant paper information: