The world's first panoramic time-space map of life announced!

Today, Cell Press released the world's first panoramic spatiotemporal map of life in the form of a special feature

Among them, the paper introducing the spatiotemporal map of mouse embryonic development was published in the journal "Cell", and the other three papers showing the spatiotemporal maps of Drosophila, zebrafish and Arabidopsis were published in the "Cell" sub-journal "Development Cell"

The research team's goal is to map the spatiotemporal development of different plant and animal species

In this latest series of studies, the Spatiotemporal Omics Consortium is using a new spatiotemporal omics technology: Stereo-seq

How did Stereo-seq achieve this giant leap? The core of its technology lies in the combination of DNA nanosphere arrays and in situ DNA capture technology: the former can amplify small DNA fragments; the latter ensures real-time imaging in living organisms

▲Stereo-seq allows scientists to obtain high-resolution transcriptomic information (Image source: Reference [1])

In one of the Cell papers, the team used Stereo-seq to examine early embryonic development in mice between days 9.

▲Stereo-seq dissects adult mouse brain structure at single-cell resolution (Image source: Reference [1])

This spatiotemporal map of mice shows the precise locations of 300,000 cells

For example, Robinow syndrome is a typical birth defect, with children with cleft lip and palate, short limbs and other symptoms

▲The study revealed the spatiotemporal map of mouse organ formation (Image source: Reference [1])

In two other papers, the research team also constructed spatiotemporal maps of embryonic development in zebrafish and fruit flies

In the final paper, the research team tackled a long-standing conundrum by studying Arabidopsis: spatial omics studies of plant leaves and other tissues at single-cell resolution

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References:

[1] Ao Chen et al.