The world's first AIDS cure, "Berlin Patient" leukemia relapse.

Timothy Ray Brown, the world's first AIDS curer once known as the "Berlin Patient," is in hospice care at his home in Palm Springs, California, as his leukaemia recurs.
's partner, Tim Hoeffgen, said in an interview, "Since he recovered, he hasn't seen HIV in his blood, it's completely gone, but leukaemia is coming again."
", but 12 years ago, it was this cancer that prompted him to receive a historic treatment.
Brown was born in 1966 and went to Berlin, Germany, where he was diagnosed with HIV-positive in 1995 and acute myeloid leukemia in 2006, and when the leukaemia relapsed after chemotherapy required a bone marrow transplant, his doctor Gero Hütter decided to make a bold effort to select a donor with the CCR5-32 mutation from 60 bone marrow donors.
Previous studies have shown that CCR5 is the primary subject of HIV virus invasion of T cells, and that the 32-bit base pair-missing mutation of the CCR5 gene (CCR5-32/32) prevents cells from expressing CCR5 cytokine complexes, thereby blocking the access of certain HIV subtypes to CD4-T cells.
, it would open up the possibility of treating both Brown's leukemia and AIDS.
In 2007, Brown received his first hematopoietic stem cell transplant, shortly after the operation, Brown's somatic cells detected a CCR5 32/32 mutation, the blood virus content was greatly reduced, but it was not long before leukemia relapsed, Brown then received the same body of hematopoietic stem cell transplant, Gero Hütter increased the efforts of myelin, trying to eliminate all cancer cells.
a second bone marrow transplant, Brown went through a vicious ghost shutdown, but eventually not only did he cure leukemia, but the HIV virus in his body dropped to dn't be detected.
published in the New England Journal of Medicine in 2009, the results caused a stir around the world.
Inception, Brown was called a "Berlin patient" at a medical conference to remain anonymous, but in 2010 he decided to open his identity to the world, giving speeches, giving interviews, insisting on assisting scientists in AIDS treatment research, and creating the Timothy Ray Brown Foundation, the World AIDS Institute, in the hope of helping more people with AIDS.
with Brown's case, many researchers are trying to replicate the success of "Berlin Patients", and in March 2019, a patient with AIDS and Hodgkin's lymphoma from London was declared cured in the same way, after stopping anti-AIDS treatment. After eight months of remission, Adam Castillejo, a "London patient" who opened up about his identity in March 2020, like Brown, hopes his experience will help more AIDS research and encourage more people living with AIDS to live actively.
Nearly 40 years have passed since the world's first case of HIV infection was discovered in 1981, during which countless scientists have worked hard to solve it, but it is still one of the world's most difficult problems to overcome, but Brown and Castilejo created a miracle in medical history, but also become the hope of tens of millions of AIDS patients.
, 54, told The Associated Press that the cancer has returned and spread widely since last year and is now in its late stages, but "I will continue to fight until I can't fight anymore."
"I'm still glad I had surgery," Brown said of his 2007 transplant, "which opened a door that didn't exist before" and inspired scientists to work harder to find a cure that many thought was impossible.
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