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Since entering the 21st century, especially since the continuous spread of the new crown pneumonia epidemic, global biotechnology has made rapid progress, the impact of major public health security events has continued to escalate, and all sectors of society have attached unprecedented importance to the bioeconomy, and the era of bioeconomy has officially begun
.
At present, more than 60 countries and regions around the world have issued strategic policies and plans related to biotechnology and bioindustry, and more and more economies have mainstreamed
the development of bioeconomy into national strategic policies.
How do you view the current general trend in the evolution of the global bioeconomy? How to grasp the development initiative in the era of bioeconomy?
General trends in the development of the global bioeconomy
General trends in the development of the global bioeconomy The era of bioeconomy has opened up another epoch-making and far-reaching stage of civilization after the era of agricultural economy, industrial economy and information economy, showing a completely different new scene
from the era of information economy.
The development of the bioeconomy will profoundly affect the production and life of human society, the way of cognition, and even energy security, national security and other aspects
.
Trend 1: The bioeconomy outlines a beautiful blueprint
for the sustainable development of human society.
for the sustainable development of human society.
At present, the wave of biotechnology revolution is sweeping the world, and life sciences have gradually become the most active field of scientific research in the world after information science
.
In the past decade, the number of papers published in the field of biology and medicine worldwide is close to half of the total number of natural science papers, and seven of the top ten scientific breakthroughs published by Science in 2021 are related to
biotechnology.
Among the top 100 R&D companies in the world, the biomedical industry accounts for nearly one-third, ranking first
.
.
In recent years, gene sequencing, gene editing and other life science general technologies with rapid development, its development costs are falling at a rate of more than Moore's Law, modern biotechnology has gradually entered thousands of households, driving the rapid development and growth of the biological industry, and the beautiful blueprint of the bioeconomy is in sight
.
In particular, modern biotechnology continues to penetrate and apply to the fields of medicine, agriculture, chemical industry, materials, energy and other fields, providing new solutions for mankind to solve major challenges such as disease, environmental pollution, climate change, food security, and energy crisis, and playing an important leading role
in promoting sustainable economic and social development.
With the accelerated application of emerging biotechnologies such as regenerative medicine and cell therapy, human cardiovascular and cerebrovascular diseases, cancer, chronic respiratory diseases, diabetes, etc.
will be overcome, effectively improving human health and prolonging human life expectancy
.
The accelerated integration of breeding technology with cross-field technologies such as whole genome selection, gene editing, high-throughput sequencing, and phenotypomics will effectively ensure food supply and improve the ecological environment
.
Biosynthesis method, bio-based materials and other technologies are widely used, and biomanufacturing products will gradually replace about one-third of petrochemical and coal chemical products in the next decade, which will create better conditions
for human green production and ecological environment restoration.
for human green production and ecological environment restoration.
Trend two: The bioeconomy may become one of the core contents of the science and technology economy strategy of
future big countries.
future big countries.
With the accelerated evolution of the bioeconomy era, some developed economies have promulgated and implemented top-level bioeconomic development strategies
.
For example, Germany released a new version of the National Bioeconomy Strategy in January 2020, following the release of the German Bioeconomy Strategy Study 2030: The Road to the Bioeconomy in November 2011; The European Union published "Innovations for Sustained Growth: The European Bioeconomy" in February 2012 and "Sustainable Bioeconomy in Europe: Strengthening Economic, Social and Environmental Linkages" in October 2018; Following the release of the National Bioeconomy Blueprint in April 2012, the United States has successively issued special bills such as engineering biology and medical innovation policies, as well as strategic documents
such as "Preparing for Future Biotechnology Products", "U.
S.
Bioeconomic Development Recommendations: Maximizing Economic Growth and National Security", and "Protecting the Bioeconomy".
As mentioned in the "Bioeconomy Policy: G7 Strategic Overview and Analysis" released by the German Bioeconomy Council in November 2017: "In recent years, the practicality and great potential of the bioeconomy have been widely recognized
worldwide.
Bioeconomic policies have become a core element of economic policy in developed economies around the
world.
"Countries have opened up different paths and policy instruments for the development of the bioeconomy based on their own resources, technology and industrial reserves
.
For example, France, Canada, Italy, the United Kingdom and other countries have established bioeconomic development strategies in key areas such as bio-based materials and bioenergy by combining their own biological resource endowments, energy supply characteristics and industrial transformation needs; In 2017, the U.
S.
R&D budget for the biomedical sector accounted for nearly half
of non-defense R&D investment.
It is foreseeable that in the context of the bioeconomic era, the bioeconomy will become the main battlefield of scientific and technological and economic competition among major countries, and the competition for biological resources, technology, talents and capital in various countries in the world will become increasingly fierce
in the future.
world.
Under the background of the bioeconomy era, the bioeconomy will become the main battlefield of scientific and technological and economic competition among major countries
Trend three: The bioeconomy will give national security a new connotation and mission
.
.
With the rapid development of cutting-edge life sciences and biotechnology such as synthetic biology, gene editing, and neuroscience, the international security situation has undergone profound changes, and traditional national security has broken through the five-dimensional space of land, sea, air, space and electricity, and the importance of biosecurity has been greatly enhanced
.
At the same time, the international biosecurity situation is grim, the research and development of biological weapons has been repeatedly prohibited, and the threat of biological warfare still exists
.
The "human weapons" and "genetic weapons" targeted at specific ethnic groups are characterized by lethality and contagion, large killing area, long harm time and difficulty of discovery
.
According to statistics, there are 20-30 kinds of pathogenic microorganisms and toxins
in the world that can be used as modern biological warfare agents.
Since entering the 21st century, public health emergencies such as avian influenza, Ebola, and Zika virus have occurred one after another around the world, and the cumulative global economic losses have reached trillions of US dollars, causing serious social harm
.
Phenomena such as invasive alien species, biotechnology abuse, bioterrorism, laboratory biosecurity loopholes, and loss of genetic resources are not uncommon
.
There are increasing
international disputes over the cross-border flow of biological resources and the cross-border development and application of biotechnology.
In September 2018, the United States for the first time released the National Biodefense Strategy, a systematic strategy to comprehensively address various biological threats, proposing five major goals
, such as enhancing biodefense risk awareness, improving biodefense risk prevention capabilities, and making biodefense preparations 。 Under the new background and new situation in the current field of biosecurity, countries and regions need to step up the layout of the development of the bioeconomy, improve the ability to prevent biosecurity risks, and accelerate the construction of a national security system adapted to the era of the bioeconomy, with a view to effectively preventing biological threats, controlling biological risks, safeguarding national sovereignty security and development interests, and jointly supporting the modernization of global security governance and the long-term peace and stability
of mankind.
International fostering practices and experiences for the development of the bioeconomy
International fostering practices and experiences for the development of the bioeconomy Since the second half of the 20th century, major developed countries and regions have attached great importance to the development and promotion of biotechnology, and have experienced ways and means from focusing on the cultivation of the field of life sciences, to supporting and promoting the biological industry as a strategic emerging industry, and then to the bioeconomy as a new economic form parallel to the industrial economy and information economy, comprehensively improving the institutional mechanism and policy ecological environment
from both the supply and demand ends.
This practice has been particularly evident
since the beginning of the 21st century, especially in the past 10 years.
General technologies of the underlying platform, such as genomics and synthetic biology, have become hot spots
.
.
In recent years, major developed countries and regions have strengthened the layout of cutting-edge leading technologies, enhanced subversive innovation, and actively seized the strategic commanding heights
in the field of bioeconomy.
Genomics, synthetic biology, computational biology and other general, platform-based underlying technologies have become the focus
of countries to increase R&D investment.
of countries to increase R&D investment.
❖ In the field of genomics, the National Institutes of Health launched the "All Of Us" project in May 2018, planning to carry out genome sequencing of 1 million people in the next 10 years; The UK government plans to sequence the genomes of 5 million people over the next 5 years; The EU plans to complete genome sequencing
of 1 million people in the EU over the next three years.
❖ In the field of synthetic biology, genome editing is one of the key technologies in the corresponding strategic planning of the United States, Japan, the European Union, Italy and Russia; In the 2019 U.
S.
Bioeconomy Action: Implementation Framework, synthetic biology techniques are applied to several of the new research areas mentioned; The UK's corresponding bioeconomy strategy explicitly supports the development of industrial biotechnology and synthetic biology as a platform technology for application in a more circular and greener bioeconomy; Singapore specifically funds synthetic biology research and development programs
.
❖ In the field of biological storage and computing, Microsoft has realized fully automatic DNA information storage, breaking through the key steps of DNA storage technology to commercial data centers; Stanford University has developed a low-energy brain "artificial synapse" to achieve computation and storage synchronization; The Swiss ETH Zurich has developed the technology "DNA of Everything", which uses DNA as a storage medium to store information in almost any object
.
Strengthen biotechnology to better support the sustainable development
of human society.
of human society.
In line with the characteristics of the era of biotechnology entering thousands of households in the era of bioeconomy, major countries and regions have deployed bioeconomic development priorities
in the face of major needs such as "medicine", "food", "beauty" and "safety" related to sustainable economic and social development.
❖ The Biomass Research and Development Council (BR&D) released the Bioeconomy Plan: Implementation Framework in March 2019 under the guidance of the previous programmatic document "National Bioeconomy Blueprint", which pointed out that in the next stage, the country will focus on advanced algal fuel systems, gene editing, biomass conversion and carbon cycle for
energy, agriculture, industry and other transformation and sustainable development needs.
❖ Canada released its first national bioeconomy strategy in May 2019, the Canadian Bioeconomy Strategy – Harnessing Strengths for a Sustainable Future, which states that it is necessary to further maximize the value of biomass and residues for the effective management
of natural resources.
❖ In July 2019, the European Bioindustry Association (EuropaBio) released the Biotechnology Industry Declaration 2019 – Revitalizing the EU's Biotechnology Ambitions, confirming the need to enhance the competitiveness of the EU biotechnology industry with the aim of innovating biotechnology for the benefit of people and the planet, and calling on EU policymakers to re-establish a healthier, more resource-efficient and biotechnology-driven Europe
.
❖ Japan's "Biological Strategy 2019 - Biocommunities for International Resonance" strategy clearly states that it will focus on the development of nine major areas related to medicine, food, housing, energy and so on, including: high-performance biomaterials, bioplastics, sustainable agricultural production systems, organic waste and wastewater treatment, health care and digital health, biomedicine and cell therapy, biomanufacturing, industry and food bioindustry, bioanalysis, measurement and experimental systems, wooden buildings and intelligent forestry management
。
Ensure the smooth integration
and coordination system and mechanism between departments.
and coordination system and mechanism between departments.
Judging from the top-level design of the bioeconomic development strategies released by major countries and regions in the past few years, the characteristics of the bioeconomy covering many fields, involving support and regulatory departments are complex, and the degree of dependence on public policies and institutional mechanisms for coordination has been agreed
.
Countries attach great importance to ensuring that the bioeconomy thrives in a smooth ecosystem of institutional mechanisms and policies by increasing intersectoral coherence and coordination
.
❖ In May 2020, a new U.
S.
Congress proposal on engineering biology research states that federal government departments should continue to strengthen coordination
with the Department of Defense, the Department of Agriculture, the Department of Health and Human Services, and other departments.
❖ The new edition of Germany's National Bioeconomy Strategy 2020 proposes that the government will appoint an independent, broad-membered, cross-border joint advisory committee to ensure that multiple goals, implementation plans and specific recommendations
are put forward with the participation of multiple relevant groups.
❖ The UK is jointly issued by the departments of commerce, energy, industry and industry, and the government, industry and research departments jointly promote the transformation
of the bioeconomy.
In addition, non-governmental think tanks, financial institutions and other industry-university-research are also important participants in
actively building and improving the bioeconomic system and mechanism.
For example, Schmidt Futures, the U.
S.
Schmidt Futures, which released its April 2022 report, "The U.
S.
Bioeconomy: Planning a Path for a Flexible and Competitive Future," was initiated
by Eric Schmidt, chairman of the National Security Council's Artificial Intelligence and Defense Innovation Committee and former CEO of Google.
The think tank established the Working Group on Synthetic Biology and Bioeconomy in October 2021, which is composed
of experts in the fields of physics, ethics, and synthetic biology, as well as venture capitalists, industry leaders, and leaders of biotechnology alliances at innovative companies.
actively building and improving the bioeconomy system and mechanism.
Continue to strengthen public participation and public opinion guidance
in bioeconomy-related decision-making.
in bioeconomy-related decision-making.
Different from the industrial economy and the information economy, the development of the bioeconomy is not only an efficiency revolution, but also related to the transformation and evolution of human life, which is closely related to natural things, so the relevant decision-making and deployment needs to introduce a public participation mechanism
.
For example, on the issue of the development and promotion of genetically modified products, both the United States, which is actively promoting GM products, and the relatively cautious European Union, have tried to disclose information in the GMO approval process and invite the public to participate
.
Practices in the United States include the need to publish an environmental impact report at the same time as the release and registration of GMOs, the need for public comment before GM foods can be marketed, and the opening of meetings of the UNEP Scientific Advisory Board on Biotechnology and the
publication of the minutes online.
The European Union requires the Food Safety Authority to issue an evaluation report on new GM products, which the Commission publishes online for a month of public comment
.
.
In addition, in view of the emerging industrial attributes of biotechnology products and services, as well as the importance of the public's "medicine", "food", "beauty" and "safety", some countries and regions have focused on actively guiding
the public's acceptance of biotechnology products and services and cultivating corresponding consumption concepts and habits 。 For example, France proposes ten major actions to support the matching of supply and demand in the bioeconomy; The UK Research and Innovation Agency will support business and academia to operate in a transparent and responsible manner to enhance public trust and publicly and effectively promote innovative bio-based products, thereby enhancing public understanding and awareness of new products and thus ensuring social, environmental and economic benefits in the transition to a bio-based economy; In "Italy's Bioeconomy: A New Bioeconomic Strategy for Sustainable Italy", Italy proposes to promote demand for bio-based products from the perspective of consumers, collect information about consumers on bio-based products, consider how to form new markets, and develop innovative and inclusive business solutions
using bio-based services.
the public to enhance the acceptance of biotechnology products and services and cultivate corresponding consumption concepts and habits.
How to grasp the development initiative in the era of bioeconomy?
How to grasp the development initiative in the era of bioeconomy? The path of cultivating and developing the bioeconomy in China is roughly divided into three stages: early and vigorous support for major technology research and development and research in the field of life sciences; In the past 20 years, we have concentrated resources to promote the development of the biological industry; In May 2022, China conformed to the general trend of the development of the global bioeconomy era and released the first national-level bioeconomic development strategy "14th Five-Year Plan" for the development of the bioeconomy, marking a new stage
in the development of China's bioeconomy 。 Entering this stage, focusing on the current new trend of the development of the international biological economy, based on the advantages of China's abundant biological resources, vast market space, large scale of the bioeconomy and sound industrial system, etc.
, we can make scientific planning, overall design, forward-looking layout and solid progress from consolidating the scientific and technological foundation, strengthening the core pillar industries, strengthening the protection, development and utilization of biological resources, building a solid biosecurity barrier, and optimizing the ecology of the bioeconomic system, and strive to grasp the initiative in development in the era of bioeconomy
.
bioeconomy.
01 Consolidate the foundation
of life science innovation.
of life science innovation.
The first is to further consolidate the technical foundation for
the prosperity and development of the bioeconomy.
Closely align with the implementation requirements of the Healthy China Strategy, and accelerate the deployment and promotion of a number of new biotechnology research plans
in the face of the "stuck neck" problem that restricts the application and promotion of biotechnology.
Strengthen the national strategic scientific and technological strength in the field of life sciences in which industry, education and research jointly participate, give full play to the advantages of the new national system, and innovate the system of
"unveiling the leader".
the prosperity and development of the bioeconomy.
Second, in the context of the trend reversal of the international scientific and technological cooperation situation, adhere to open innovation, recruit all kinds of talents and teams at home and abroad, make better use of specialized innovation and entrepreneurship capital at home and abroad, strengthen cross-border scientific and technological cooperation projects, and reduce institutional obstacles
to cooperation in innovation elements.
The third is to strengthen a number of industrial clusters, guide innovation resources to further incline areas with accumulation in the early stage, foundation, and potential in the future, for example, vigorously support the construction of key biological industry clusters such as Suzhou, Shanghai, Guangzhou, Chengdu, and Wuhan, so that they can become an important force
driving regional industrial transformation and upgrading and supporting the leapfrog development of China's bioeconomy.
02 Cultivate and expand emerging pillar industries
.
.
Accelerate the extensive empowerment of biotechnology to health, agriculture, energy, environmental protection and other industries, promote the deep integration of biotechnology and information technology, and accelerate the growth of bioeconomic pillar industries
.
The first is to promote the development of the medical and health industry
.
Starting from disease prevention, diagnosis and treatment, focus on the development of early screening of major diseases using genetic testing and other means, support the development of individualized treatment and precision treatment, and accelerate the iterative upgrading of vaccine research and development and production technology; Promote the integration of biotechnology with precision machinery, materials and other technologies, develop advanced diagnostic technologies and products and equipment, and strengthen the study of the efficacy and mechanism of traditional Chinese medicine; In the disease medical link, promote the development of biological drugs such as antibody drugs, promote the development of original drugs for major diseases and rare diseases, expand the clinical application of advanced treatment technologies, standardize the clinical application of new technologies such as cell therapy, and encourage the integration
of traditional Chinese medicine and Western medicine.
.
The second is to promote the development of
biological agriculture.
Grasp the improvement of production capacity and quality of important agricultural products such as grain and other agricultural products, orderly develop biological breeding technologies such as whole genome selection and synthetic biology, ensure the supply of important agricultural products such as grain, meat, eggs and milk, and oilseeds, actively promote corn, soybeans and other crops, livestock and poultry, and aquatic products, and explore the research and development of new foods such as "artificial protein"; On the one hand, we should improve the efficiency of agricultural production, develop agricultural waste biological preparations, natural agricultural biological drugs and other agricultural products, promote the research and development and industrialization of animal genetic engineering vaccines, efficient detection reagents and other technologies, and develop biological feeds
such as enzyme preparations and microbial preparations.
biological agriculture.
The third is to promote the development of
biomass applications.
Facing the major needs of the transformation of green, low-carbon and sustainable development models, we will actively develop biomanufacturing technology, realize the biotechnology substitution of chemical raw materials and processes, develop high-performance bio-environmental protection materials and biologics, and promote the deep integration
of manufacturing and biotechnology of important industrial products such as chemicals, medicines, materials, and light industry.
biomass applications.
The fourth is to encourage the development of the bioinformation industry
.
Continue to tap the huge innovation efficiency and industrial momentum generated by the integration and application of biotechnology and information technology, promote the role of information technology in supporting the development of new drugs, use "Internet + health" and other means to optimize convenient services, and deepen the application
of health big data in medical scientific research, education and training, clinical diagnosis and treatment, product development, medical insurance payment, and medical and nursing integration.
.
03 Strengthen the conservation and utilization of biological resources and the establishment of
biosecurity systems.
biosecurity systems.
On the one hand, more efficient and deeper protection of the development and utilization of biological resources
.
First, attach equal importance to soft environment and hard facilities, increase the protection of biological resources, improve the supervision system of biological resources, carry out a comprehensive census, find out the family background, improve technology, and plan to build a number of high-standard treasure houses
of biological resources.
The second is to improve the development and utilization system of biological resources, strengthen scientific evaluation, strengthen the support of the platform for the utilization of biological resources, and promote the comprehensive utilization
of biological resources.
The third is to strengthen the safety management of biological resources and improve the biological resource sharing system
at the national level.
.
On the other hand, it is necessary to build a solid biosecurity guarantee system
.
The first is to increase efforts to improve the level of
governance modernization.
Accelerate the establishment of an overall coordination mechanism for promoting the development of the bioeconomy, study the establishment of a leading group for the development of the bioeconomy, accelerate the construction of a forward-looking institutional framework around the development, utilization, production, distribution, exchange, consumption and biosecurity of biological resources, and continuously improve the construction of a bioeconomic legal system with strong adaptability and pertinence, and a biosecurity and ethical risk prevention and control system
that adapts to national conditions.
The second is to improve the production capacity level of production enterprises in the
biological field.
Under the premise of ensuring safety, relax the production access conditions for related products, improve the industrial chain from research and development to production, preparation, consumables and related supporting industries, and ensure that special materials such as vaccines, medical consumables and civil health products are supplied
during the emergency period of public health and safety events.
The third is to strengthen the popularization
of bioeconomic science.
In view of the public's panic about emerging infectious diseases, doubts about the efficacy and safety of new medical technologies and services, and the environmental friendliness of biotechnology products, strengthen scientific publicity, public opinion supervision, correct guidance and typical reports, help the public enhance scientific understanding, reduce unnecessary doubts and panic
.
.
04 Continue to optimize institutional mechanisms and policy ecology
.
.
On the supply side, it is necessary to continue to deepen market access and regulatory reform
.
Adhere to bottom-line supervision and prudential supervision, focus on promoting the reform of market access for biotechnology products and services, and further clarify product access standards, regulatory agencies and relevant time limits
.
.
On the demand side, efforts should be made to deepen the reform of the bidding procurement and pricing system
.
It is necessary to give play to the role of government procurement in leveraging the market, encourage qualified and potential regions to implement more government application demonstration projects for biological products and services, increase the public's awareness and acceptance of biotechnology products and services, establish and improve in advance the public decision-making mechanism for disputes on major issues involving ethics and safety bottom lines, and continue to regulate the market order of products and services and the quality of
supporting services.
.
In addition, it is necessary to strengthen the overall coordination of the development of the biological economy, in view of the characteristics of many types of biological products, long chains, and many management departments, focus on the formation of an innovation chain and industrial chain for the benign development of the biological industry, coordinate all aspects of the production, circulation and use of biotechnology products, establish a management system that adapts to the development of the biological economy, and improve the continuity and predictability of
regulatory policies 。 In the Beijing-Tianjin-Hebei, Yangtze River Delta, Guangdong-Hong Kong-Macao Greater Bay Area, Chengdu-Chongqing Twin Cities Economic Circle and other regions, the city as the carrier layout to build bioeconomic pilot zones, around the biomedicine, bio-agriculture, bioenergy, bio-environmental protection and other fields to carry out scientific and technological innovation and reform pilots, focusing on gathering global innovation resources, access, pricing, supervision and other institutional mechanisms to explore the construction of a forward-looking institutional framework and policy implementation system
that adapts to the era of bioeconomy.