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Trazodone hydrochloride is a widely used antidepressant medication that belongs to the class of drugs known as serotonin antagonist and reuptake inhibitors (SARIs).
The chemical formula for trazodone hydrochloride is C10H12N2S tempo floor-9-chloride (hydrochloride) and it has a molecular weight of 265.
7 g/mol.
Trazodone hydrochloride is typically formulated as a racemic mixture of two enantiomers, with the (R)-enantiomer being more pharmacologically active than the (S)-enantiomer.
Trazodone hydrochloride is a white to slightly yellowish crystalline powder that is soluble in water, and it has a bitter taste.
Trazodone hydrochloride is used to treat depression, anxiety disorders, and trouble sleeping (insomnia).
Upstream and Downstream Products of Trazodone Hydrochloride
The production of trazodone hydrochloride involves several stages, including the synthesis of the raw materials, the manufacture of the active pharmaceutical ingredient (API), and the formulation of the final product.
The upstream products and downstream products of trazodone hydrochloride are discussed below.
Upstream Products
The upstream products of trazodone hydrochloride include the raw materials used in its production and the intermediate products that are generated during the synthesis of the API.
Raw Materials:
The raw materials used in the production of trazodone hydrochloride include chemicals such as chlorine gas, ethyl acetate, ethanol, toluene, and sodium hydroxide.
These chemicals are obtained from various suppliers and are subject to strict quality control procedures to ensure their purity and composition.
Intermediate Products:
The intermediate products of trazodone hydrochloride include the precursors and reagents used in the synthesis of the API.
These include products such as 3-(3,4-dichlorophenyl)-1,2,4-triazine-2,5-diamine, which is synthesized from chlorine gas and ethyl acetate, and 1,2-dimethyl-3-(3,4-dichlorophenyl)-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9(10H)-one, which is synthesized from 3-(3,4-dichlorophenyl)-1,2,4-triazine-2,5-diamine and other reagents.
These intermediate products are generated in various stages of the synthesis process and are typically purified and characterized before being used in the next step of the process.
Downstream Products
The downstream products of trazodone hydrochloride include the final product, which is the medication that is prescribed to patients, and various formulations and dosage forms that are used to deliver the medication to patients.
Final Product:
The final product of trazodone hydrochloride is a racemic mixture of the (R)- and (S)-enantiomers of the API, which is used to treat depression, anxiety disorders, and trouble sleeping.
This product is typically provided in tablet or capsule form and is prescribed to patients by healthcare providers.
Formulations and Dosage Forms:
The final product of trazodone hydrochloride is often formulated into various dosage forms, including tablets, capsules, and liquids, to provide patients with a range of options for taking their medication.
These formulations are designed to optimize the bioavailability, efficacy, and safety of the medication, and they may include various excipients, such as fillers, binders, and coatings, to improve the properties of the final product.
Conclusion
In conclusion, the production of trazodone hydrochloride involves various stages, including the synthesis of raw materials, the manufacture of the API, and the formulation of the final product.
The upstream products of trazodone hydrochloride
