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    Home > Medical News > Medical World News > The Upstream and Downstream products of THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE

    The Upstream and Downstream products of THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE

    • Last Update: 2023-05-16
    • Source: Internet
    • Author: User
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    Thieno[3,2-d]pyrimidin-4(3H)-one, also known as TDP for short, is an important intermediate compound in the chemical industry.
    It is often used in the production of various pharmaceuticals, agrochemicals, and dyestuff intermediates.
    TDP has two types of products: upstream and downstream products.


    Upstream products refer to the raw materials or starting materials that are required to produce TDP.
    Two common upstream products for TDP are 2-pyrimidinethiol and 2-thiouracil.
    These two compounds can be derived from other precursors such as pyrimidine-5-carboxylic acid or 2-mercaptoethanol, respectively.


    The production of TDP begins with the reaction of these upstream products in a reaction called the Hofmann elimination.
    This reaction involves the reduction of a carbonyl group to form a double bond, followed by the rearrangement of the resulting pyrane ring.
    The net result is the formation of TDP.


    Downstream products, on the other hand, refer to the products that are derived from TDP.
    These products are often used as intermediate compounds in the production of various pharmaceuticals, agrochemicals, and dyestuffs.
    Some examples of downstream products include:


    • 5-Fluoro-2-oxazole: This compound is used in the production of certain antibiotics and anti-inflammatory drugs.
    • 8-Fluoro-2'-deoxyguanosine: This compound is used in the production of antiviral drugs and is also used in research on DNA damage and repair.
    • Enamine: This is a versatile intermediate that can be used in the production of various pharmaceuticals, agrochemicals, and dyestuffs.
    • N-(1-aziridinyl)-1,2-dihydroquinoline-3-amine: This compound is used in the production of certain antibiotics and anti-inflammatory drugs.

    It is important to note that both upstream and downstream products can also be further processed to produce other intermediate or final products.
    For example, TDP can be further processed to produce 2-pyrimidinylamine, which is used in the production of certain herbicides.
    Similarly, 5-Fluoro-2-oxazole can be further processed to produce certain antibiotics.


    In the chemical industry, the production of both upstream and downstream products is an important aspect of the supply chain.
    Upstream products are often produced by specialized companies and then sold to downstream companies that use them to produce their own products.
    The supply chain is carefully managed to ensure a steady and reliable supply of raw materials and intermediates.


    In conclusion, TDP is an important intermediate compound in the chemical industry that is used in the production of various pharmaceuticals, agrochemicals, and dyestuffs.
    It has two types of products, upstream and downstream products, that are used in different stages of the production process.
    The production of TDP involves several steps and different intermediates and the process is managed by experts.
    The chemical industry is a complex system and the management of the supply chain is essential for the production of the final product.


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