The Upstream and Downstream products of Methyl5-bromo-2-(methylsulfonyl)pyrimidine-4-carboxylate

Methyl5-bromo-2-(methylsulfonyl)pyrimidine-4-carboxylate, also known as MESC, is a molecule that has a wide range of applications in the chemical industry.
This compound is used as an intermediate in the production of various chemical products, and it is also used as a precursor for the synthesis of other molecules.
In this article, we will focus on the upstream and downstream products of MESC, and how it is used in the chemical industry.

Upstream products of MESC

The production of MESC involves several steps, and it typically begins with the synthesis of 5-bromo-2-(methylsulfonyl)pyrimidine, also known as BMSP.
This molecule is synthesized by reacting 2-methylthio-5-bromopyrimidine with hydrogen sulfate in the presence of a Lewis acid catalyst.
The product is then converted to 5-bromo-2-(methylsulfonyl)pyrimidine-4-boronic acid, which is subsequently reduced with diborane to give 5-bromo-2-(methylsulfonyl)pyrimidine-4-carboxylate, also known as MESC.

Downstream products of MESC

The primary use of MESC is as an intermediate in the production of other chemical products.
One of the most common downstream products of MESC is the antiviral drug Valcyte, which is used to treat cytomegalovirus infections.
Valcyte is synthesized by reacting MESC with 2-oxoglutaric acid in the presence of a palladium catalyst.

Another downstream product of MESC is N-acetylcysteine, which is used as a mucolytic agent and a thiol-based antioxidant.
N-acetylcysteine is synthesized by reacting MESC with acetyl chloride in the presence of a Lewis acid catalyst.

Other downstream products of MESC include 1-[(2S)-2-(methylsulfonyl)pyrrolidin-1-yl]-3-[(phenylsulfonyl)amino]-5-even-1,2-dioxaborole, which is used as an intermediate in the synthesis of Bortezomib, a proteasome inhibitor used to treat multiple myeloma, and 4-[[[(4S)-4-(difluoromethyl)-2-(methylsulfonyl)pyrimidin-1-yl]amino]carbonyl]benzenesulfonic acid, which is used as a intermediate in the synthesis of tolperisone, an antihistamine and anticholinergic drug.

In conclusion, MESC is an important intermediate in the production of a wide range of chemical products.
The upstream products of MESC include 2-methylthio-5-bromopyrimidine and 5-bromo-2-(methylsulfonyl)pyrimidine-4-boronic acid, while the downstream products include Valcyte, N-acetylcysteine, 1-[(2S)-2-(methylsulfonyl)pyrrolidin-1-yl]-3-[(phenylsulfonyl)amino]-5-even-1,2-dioxaborole, and 4-[[[(4S)-4-(difluoromethyl)-2-(methylsulfonyl)pyrimidin-1-yl]amino]carbonyl]benzenesulfonic acid.

MESC is an essential intermediate in the production of various chemical products, and it