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Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate, also known as ETU, is an organic compound that is commonly used as an intermediate in the production of various chemicals and pharmaceuticals.
ETU belongs to a group of chemicals known as pyrazoles, which are synthesized from various starting materials and are used in a wide range of applications in the chemical industry.
Upstream Products
ETU is an intermediate chemical that is used in the production of several other chemicals and pharmaceuticals.
The upstream products that are derived from ETU include several important chemical intermediates, such as 2,3-dihydroxy-5-nitrobenzaldehyde, which is used in the production of dyes and pigments, and N-(2,3-dihydroxyphenyl)acetamide, which is used as a reactant in the production of pharmaceuticals and other chemicals.
Downstream Products
The most common downstream products of ETU are pharmaceutical intermediates and active ingredients.
ETU is used as an intermediate in the production of several important pharmaceuticals, including immunosuppressants, anti-inflammatory drugs, and antibiotics.
One of the most important downstream products of ETU is the immunosuppressant drug FK506, which is used to prevent the rejection of transplanted organs.
FK506 is synthesized from ETU using a series of chemical reactions, which involve the introduction of various functional groups onto the ETU molecule.
Another important downstream product of ETU is the anti-inflammatory drug nabumetone, which is used to treat pain and inflammation in conditions such as osteoarthritis.
Nabumetone is synthesized from ETU using a similar series of chemical reactions as those used to synthesize FK506.
Finally, ETU is also used as an intermediate in the production of the antibiotic drug erythromycin.
Erythromycin is synthesized from ETU using a series of chemical reactions that involve the addition of various functional groups onto the ETU molecule.
Chemical Reactions
ETU is synthesized from various starting materials using a series of chemical reactions.
One of the most common methods for synthesizing ETU involves the reaction of chloroacetic acid with 2,4-diaminophenoxyacetic acid (DAPA) in the presence of a solvent such as dichloromethane.
This reaction results in the formation of ETU, which can then be isolated and purified using various chemical techniques.
Once ETU has been synthesized, it can be converted into various downstream products using a variety of chemical reactions.
These reactions typically involve the addition of various functional groups onto the ETU molecule, such as halogens, nitro groups, and other organic groups.
The specific reactions used to synthesize each downstream product depend on the desired product and the specific synthesis route.
Production and Supply Chain
ETU is produced by chemical companies in large quantities and is distributed to various manufacturers and chemical suppliers worldwide.
The production and supply chain of ETU are highly efficient, with most manufacturers using standardized synthesis routes and purification techniques to ensure consistent quality and availability of the product.
In terms of production, ETU can be synthesized using various methods, including traditional chemical synthesis methods as well as more modern methods such as combinatorial chemistry and high-throughput screening.
The choice of synthesis method depends on the specific needs of the manufacturer and the desired product.
Market and Demand
The demand for ETU and its down