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6-Chloro-4(3H)-quinazolinone, also known as 6-chloro-4H-quinazoline-2,4-dione, is a synthetic chemical compound that is commonly used as an intermediate in the production of various chemicals and pharmaceuticals.
The compound is synthesized from simpler precursors, and it is used as a building block for the synthesis of final products in the chemical industry.
In this article, we will discuss the upstream and downstream products of 6-chloro-4(3H)-quinazolinone.
Upstream Products
The upstream products of 6-chloro-4(3H)-quinazolinone are the precursors that are used to synthesize the compound.
These precursors are typically found in nature or are synthesized from other chemicals.
The upstream products of 6-chloro-4(3H)-quinazolinone are:
- Chlorinated derivatives of benzene: These compounds are used as building blocks for the synthesis of 6-chloro-4(3H)-quinazolinone.
They can be synthesized by chlorinating benzene in the presence of a Lewis acid catalyst. - Hydrochloric acid: Hydrochloric acid is used as a catalyst in the synthesis of 6-chloro-4(3H)-quinazolinone from chlorinated derivatives of benzene.
Downstream Products
The downstream products of 6-chloro-4(3H)-quinazolinone are the final products that are synthesized using the compound as a building block.
These products are typically used in the production of pharmaceuticals, agrochemicals, and other chemicals.
Some of the downstream products of 6-chloro-4(3H)-quinazolinone are:
- Pharmaceuticals: 6-chloro-4(3H)-quinazolinone is used in the synthesis of certain pharmaceuticals, such as anti-malarial drugs, anti-epileptic drugs, and anti-cancer drugs.
- Agrochemicals: 6-chloro-4(3H)-quinazolinone is used as an intermediate in the synthesis of certain agrochemicals, such as herbicides and insecticides.
- Other chemicals: 6-chloro-4(3H)-quinazolinone is used in the synthesis of other chemicals, such as dyes, fragrances, and polymers.
Processes for Synthesizing 6-Chloro-4(3H)-Quinazolinone
There are several processes that can be used to synthesize 6-chloro-4(3H)-quinazolinone, but the most common process is the Chalcone process.
The Chalcone process involves the following steps:
- Preparation of thechromium(VI) oxide catalyst: The chromium(VI) oxide catalyst is prepared by reducing chromium(VI) oxide with sodium metal in the presence of a solvent, such as toluene.
- Hydrolysis of the benzaldehyde derivative: Benzaldehyde is treated with hydrogen chloride in the presence of the chromium(VI) oxide catalyst to form a benzene derivative.
- Chlorination of the benzene derivative: The benzene derivative is chlorinated using chlorine gas in the presence of the chromium(VI) oxide catalyst to form a chlorinated derivative of benzene.
- Hydrochlorination of the chlorinated derivative: The chlorinated derivative is treated with hydrochloric acid in the presence of the chromium(VI) oxide catalyst