The Upstream and Downstream products of 5-Pyrimidinecarboxaldehyde, 2-(1,1-dimethylethyl)- (9CI)

5-Pyrimidinecarboxaldehyde, 2-(1,1-dimethylethyl)- (CAS No.
9CI) is a synthetic chemical compound that is widely used in the chemical industry.
It is an important building block for the synthesis of various downstream products, and its properties make it a versatile and valuable intermediate in the production of several chemicals.
In this article, we will discuss the upstream and downstream products of 5-Pyrimidinecarboxaldehyde, 2-(1,1-dimethylethyl)- (9CI) in the chemical industry.

Upstream Products
The upstream products of 5-Pyrimidinecarboxaldehyde, 2-(1,1-dimethylethyl)- (9CI) are the raw materials required for its synthesis.
These raw materials include p-xylene, acetaldehyde, and dimethylamine.
p-Xylene is an aromatic hydrocarbon that is derived from the distillation of petroleum.
Acetaldehyde is a colorless liquid that is produced by the hydrolysis of acetylene.
Dimethylamine is a liquid that is produced by the reduction of nitrogen gas with methanol.

The synthesis of 5-Pyrimidinecarboxaldehyde, 2-(1,1-dimethylethyl)- (9CI) involves several steps, including the condensation of p-xylene and acetaldehyde to produce a substituted acetaldehyde derivative.
This derivative is then reduced with sodium borohydride to produce the 5-Pyrimidinecarboxaldehyde.
This process is known as a controversial synthesis and is classified as Tier 1 by the European Union (EU) and California’s Proposition 65 (CA).

Downstream Products
The downstream products of 5-Pyrimidinecarboxaldehyde, 2-(1,1-dimethylethyl)- (9CI) are the chemicals that are derived from it.
These chemicals have a wide range of applications in various industries, including the pharmaceutical, agricultural, and personal care industries.

One of the most important downstream products of 5-Pyrimidinecarboxaldehyde, 2-(1,1-dimethylethyl)- (9CI) is the anticancer drug, 5-Fluorouracil (5-FU).
5-FU is widely used in the treatment of various types of cancer, including colon, breast, and stomach cancer.
It works by inhibiting the growth and proliferation of cancer cells.
5-FU is administered as a prodrug, which is converted to the active metabolite, 5-Fluorodeoxyuridine (FUDR) by the enzyme, thymidine phosphorylase.
FUDR then binds to thymidylate synthase and inhibits its function, leading to the inhibition of cancer cell growth.

Another important downstream product of 5-Pyrimidinecarboxaldehyde, 2-(1,1-dimethylethyl)- (9CI) is the herbicide, Paraquat.
Paraquat is a powerful herbicide that is widely used for the control of weeds in agriculture.
It works by inhibiting the activity of the enzyme, dihydrofolate reductase, which is required for the synthesis of folic acid.
The inhibition of this enzyme leads to the accumulation of toxic metabolites, which leads to the death of the plant cells.

In addition to 5-FU and Paraquat, 5-Pyrimidinecarboxaldehyde, 2-(1,1-dim