The Upstream and Downstream products of 3-Pyridazinecarboxylicacid,6-amino-,methylester(6CI,9CI)

3-Pyridazinecarboxylicacid,6-amino-,methylester(6CI,9CI) is an organic compound that is used as an intermediate in the production of various chemicals and pharmaceuticals.
This compound is also known as methyl 3-pyridinecarboxylate or MPC.

Upstream Products

The production of 3-Pyridazinecarboxylicacid,6-amino-,methylester(6CI,9CI) involves several upstream processes, including the synthesis of precursor compounds and their subsequent transformation into MPC.

One of the key upstream products is pyridine, which is used as a precursor to synthesize 3-pyridazinecarboxylic acid.
Pyridine is produced through the nitration of toluene, followed by hydrogenation of the resulting nitro compound.

Another upstream product is oxalic acid, which is used in the synthesis of 3-pyridazinecarboxylic acid.
Oxalic acid is produced through the oxidation of malonic acid, which is then hydrolyzed to form oxalic acid.

Downstream Products

Once 3-Pyridazinecarboxylicacid,6-amino-,methylester(6CI,9CI) is synthesized, it is used as an intermediate in the production of several downstream products.

One of the most important downstream products is L-phenylalanine, an essential amino acid used in the production of protein-based pharmaceuticals.
MPC is used as a precursor to L-phenylalanine through a sequence of chemical reactions, including esterification, hydrolysis, and nitrogenation.

Another important downstream product is L-proline, another essential amino acid used in the production of protein-based pharmaceuticals.
MPC is used as a precursor to L-proline through a similar sequence of chemical reactions as for L-phenylalanine.

MPC is also used as a precursor to other chemical intermediates and active pharmaceutical ingredients (APIs).
For example, it is used in the production of blood pressure medications, anticonvulsants, and immunosuppressants.

Chemical Reactions

The production of 3-Pyridazinecarboxylicacid,6-amino-,methylester(6CI,9CI) involves several chemical reactions, including esterification, hydrolysis, and nitrogenation.

Esterification involves the reaction of an alcohol with an acid to form an ester.
In the case of MPC, the alcohol used is methanol, and the acid is oxalic acid.
The reaction is catalyzed by a strong acid catalyst, such as hydrochloric acid, and results in the formation of methyl 3-pyridinecarboxylate.

Hydrolysis involves the breakdown of an ester into its component acids.
In the case of MPC, the ester is methyl 3-pyridinecarboxylate, and the acid is hydrochloric acid.
The reaction is typically carried out in water at an elevated temperature and results in the formation of 3-pyridazinecarboxylic acid.

Nitrogenation involves the introduction of a nitrogen group into a molecule.
In the case of MPC, the nitrogen group is introduced through the reaction of ammonia with the carboxylic acid.
The reaction is typically carried out in the presence of a metal catalyst, such as iron or cobalt, and results in the formation of methyl 3-pyridinecarboxylate.

Production Process

The production of 3-Pyridazinecarboxylicacid,6-amino-,methylester(