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2-Chloro-5-nitropyrimidine, also known as CAP, is an important intermediate chemical used in the production of several downstream products in the chemical industry.
In this article, we will discuss the upstream and downstream products of 2-chloro-5-nitropyrimidine.
Upstream Products
The production of 2-chloro-5-nitropyrimidine involves several upstream processes, including the synthesis of precursor chemicals and their subsequent conversion into the desired intermediate product.
One of the key upstream products for the production of 2-chloro-5-nitropyrimidine is 2,4-diaminophenoxyacetic acid, which is used as a precursor in the manufacturing process.
This compound is synthesized by a series of chemical reactions involving the reaction of aniline with nitric acid, followed by the addition of a secondary amine.
Another important upstream product for the production of 2-chloro-5-nitropyrimidine is chloroform, which is used as a solvent in the manufacturing process.
Chloroform is synthesized by the reaction of chlorine with methane, followed by the addition of sodium hydroxide.
The resulting compound is then purified and used as a solvent in the production of 2-chloro-5-nitropyrimidine.
Downstream Products
2-Chloro-5-nitropyrimidine is used as an intermediate in the production of several downstream products in the chemical industry.
One of the most important downstream products is 5-nitro-2-pyrimidine, which is used as a raw material in the production of dyes, pigments, and pharmaceuticals.
This compound is synthesized by the reduction of 2-chloro-5-nitropyrimidine using hydrogen in the presence of a catalyst such as palladium on barium sulfate.
Another important downstream product of 2-chloro-5-nitropyrimidine is 2,4-diamino-6-methoxy-pyrimidine, which is used as a precursor in the production of agricultural chemicals and pharmaceuticals.
This compound is synthesized by the oxidation of 2-chloro-5-nitropyrimidine using nitric acid, followed by the addition of a secondary amine.
In addition to these downstream products, 2-chloro-5-nitropyrimidine is also used in the production of other chemicals such as 2,6-diaminopyridine, which is used in the production of stabilizers for plastics, and 4-chloro-5-(2-nitrophenylamino)isoquinoline, which is used in the production of dyes and pigments.
Manufacturing Process
The manufacturing process for 2-chloro-5-nitropyrimidine involves several steps, including the synthesis of precursor chemicals and their subsequent conversion into the desired intermediate product.
The process typically involves the following steps:
- Synthesis of 2,4-diaminophenoxyacetic acid: This compound is synthesized by a series of chemical reactions involving the reaction of aniline with nitric acid, followed by the addition of a secondary amine.
- Chlorination of 2,4-diaminophenoxyacetic acid: The 2,4-diaminophenoxyacetic acid is chlorinated using chlorine gas, which converts it into 4-chloro-2,6-diaminophenoxyacetic acid.
- Reduction of 4-chloro-2,6-diaminophenoxyacetic acid: The