The Upstream and Downstream products of 2-[1-(4-Methylphenyl)-1H-pyrazol-5-yl]pyrimidine

2-[1-(4-Methylphenyl)-1H-pyrazol-5-yl]pyrimidine, commonly referred to as 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine, is an organic compound that has various applications in the chemical industry.
It is primarily used as an intermediate in the production of several downstream products.
In this article, we will discuss the upstream and downstream products of 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine.

Upstream Products

The production of 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine involves several upstream processes.
One of the primary upstream products is 1-(4-Methylphenyl)-1H-pyrazol-5-amine.
This compound is synthesized by the reaction of 4-Methylphenylamine with chlorosulfonic acid, followed by treatment with sodium carbonate.
The resulting compound is then reduced with lithium aluminum hydride to yield 1-(4-Methylphenyl)-1H-pyrazol-5-amine.

Another upstream product is phenylhydrazine, which is used in the synthesis of 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine.
Phenylhydrazine is prepared by the reaction of phenylamine with hydrazine in the presence of a strong base such as sodium hydroxide.

Downstream Products

4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine is primarily used as an intermediate in the production of several downstream products, including pharmaceuticals, agrochemicals, and dyestuffs.

One of the most important downstream products of 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine is 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine-2,4-diamine, which is used in the production of the anti-HIV drug, Emtriva (TM).
This compound is synthesized by the reaction of 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine with formaldehyde and para-aminophenol in the presence of a strong acid catalyst such as sulfuric acid.

Another downstream product is 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine-4,6-diamine, which is used in the production of the herbicide, Weedol (TM).
This compound is synthesized by the reaction of 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine with para-aminophenol and formaldehyde in the presence of a strong acid catalyst such as sulfuric acid.

4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine is also used in the production of dyestuffs, particularly in the synthesis of certain azo dyes.

Production Process

The production process of 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine typically involves several steps, including synthesis of the upstream products, purification, and transformation into the desired downstream products.

The synthesis of 4-Methyl-5-(1H-pyrazol-1-yl)pyrimidine typically involves the reaction of 1-(4-Methylphenyl)-1H-pyrazol-5-amine with phenylhydrazine in the presence of a strong acid catalyst such as sulfuric acid