The Upstream and Downstream products of 1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline

The 1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline, commonly known as 7-Nitroquinoxaline, is a chemical compound that is used in several industrial applications.
The compound is produced through a series of chemical reactions, and the product is used as an intermediate in the production of several downstream products.
In this article, we will discuss the upstream and downstream products of 1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline.

Upstream Products

The production of 1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline involves several upstream chemicals and processes.
The main upstream products used in the production of 7-Nitroquinoxaline are ethyl iodide, acetonitrile, nitric acid, and quinoline.
The ethyl iodide and acetonitrile are used as reagents in the production of 7-Nitroquinoxaline, while nitric acid and quinoline are used as catalysts and solvents, respectively.

Downstream Products

The primary downstream product of 1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline is the pharmaceutical drug, Cethrin.
Cethrin is an antihistamine drug that is used to treat allergy symptoms.
The production of Cethrin involves several chemical reactions, including the reduction of 7-Nitroquinoxaline to 1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline.
The reduction reaction is typically carried out using hydrogen gas and a metal catalyst, such as palladium on barium oxide.

In addition to Cethrin, 1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline is also used as an intermediate in the production of several other pharmaceuticals.
For example, it can be reduced to 7-Nitroquinoxaline-2,3-dione, which is used as an intermediate in the production of the antihistamine drug, Astemizole.

Other downstream products of 1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline include dyes, pigments, and other organic chemicals.
The compound can be used as a precursor in the production of diazo dyes, such as Sudan Red and Sunset Yellow.
It can also be used in the production of phthalocyanine pigments, which are used in plastics, inks, and coatings.

Manufacturing Process

The production of 1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline involves several steps, including the synthesis of ethyl iodide, the reaction of acetonitrile with hydrogen chloride, the reaction of nitric acid with quinoline, and the reduction of 7-Nitroquinoxaline to 1-Ethyl-7-nitro-1,2,3,4-tetrahydroquinoline.
The steps involved in the manufacturing process are as follows:

Step 1: Synthesis of Ethyl Iodide

Ethyl iodide is synthesized by treating ethylene with hydrogen iodide in the presence of a Lewis acid catalyst, such as aluminum chloride.

Step 2: Reaction of Acetonitrile with Hydrogen Chloride

Acetonitrile is treated with hydrogen chloride in the presence of a solvent, such as benzene, to form chloroacetonitrile.

Step 3