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Like humans, every cell in our body is trying to avoid death as much as possible
.
This is especially true for a specific type of immune cell called T lymphocytes (T cells for short)
How T cells survive in the human body for so long, even for decades, has been unclear for a long time
.
In collaboration with scientists from the Department of Biomedicine and sciCORE, the University of Basel’s Scientific Computing Center, Professor Jean Pieters’ research team at Biozentrum has now revealed the existence of a hitherto unrecognized pathway to promote the long-term survival of T cells
Coronin 1
In early research, Pieters' team and others have shown that coronin 1 is essential for the survival of peripheral T cells, as well as for their production and maturation
.
In their current research, the team has now been able to show that the pathway previously thought to be related to T cell survival is actually independent of coronin 1.
In order to find this approach that relies on coronin 1, the researchers set up a program to collect high-purity T cells, and then analyze the entire RNA molecules in normal and coronin-1 deficient T cells
.
Somewhat unexpectedly, an in-depth bioinformatics analysis of a large amount of data did not find any difference between the two groups of T cells
Researchers reveal unknown pathways
Surprisingly, there is a positive match between coronin 1-dependent T cell survival and the pathway of lipid kinase PI3Kdelta to modify the plasma membrane
.
With the assistance of Professor Matthias Wyman, a PI3K expert in the Department of Biomedicine, the researchers pieced together the various parts of the puzzle, making them realize that coronin 1 maintains the activity of PI3Kdelta and in this way inhibits the death of T cells
Pieters said: "Follow-up studies on these findings will be exciting, not only to understand the role of other members of the coronavirus family in cell survival, but also to understand how cell populations, such as circulating T cells in the blood, are maintained for a long time.
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Journal Reference :
Mayumi Mori, Julie Ruer-Laventie, Wandrille Duchemin, Philippe Demougin, Tohnyui Ndinyanka Fabrice, Matthias P.
