The Tu Pengfei team at Peking University School of Pharmacy revealed new targets for the role of Chinese medicine
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Last Update: 2020-12-10
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Source: Internet
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Author: User
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With the support of the National Natural Science Foundation of China project, Tu Pengfei, a professor at the National Key Laboratory of Natural Medicine and Bionic Drugs at Peking University School of Pharmacy, has revealed that the direct target protein of sumosterone A, the anti-neuro-inflammatory active ingredient of traditional Chinese medicine Sumu, is creatinine-5-monophosphate dehydrogenase 2 (IMPDH2), and the results are published online on
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Tu Pengfei team introduced the molecular probe concept in the field of current chemical biology into the target identification of the active ingredients of Chinese medicine, and found that creaside-5-monophosphate dehydrogenase 2 (IMPDH2) is a key target for its anti-neuro-inflammatory role. Further research also found that Sumosterone A can induce the modification of the target protein IMPDH2 co-price, and then induce its mutation inactivation, inhibit the activation of multiple inflammatory-related signaling path paths downstream of the target protein, and finally achieve anti-neuroinflammation. The results of this research not only reveal the anti-inflammatory action of the active ingredient of Chinese medicine, sumosterone A, but also find a brand-new drug action point on the IMPDH2 protein, which is of guiding significance for the design and development of anti-inflammatory and immunosuppressive drugs with IMPDH2 protein as the target in the future
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