The top 10 analgesic varieties account for over 80% of public hospitals in key cities, and the champion is

Wonderful content October 11, 2017 is the fourteenth "world analgesia day", and "safe medication, green analgesia" is another new theme With the development of society, chronic pain has been paid more and more attention The first and most subjective feeling in a person's life is pain It is our eternal topic to fully understand pain relief and no longer suffer from pain Up to now, drug analgesia has been an important means, which has also aroused people's attention to analgesic drugs   none="shifuMouseDownStyle('shifu_bus_002')" style="margin: 1em auto; padding: 0px; max-width: 100%; color: rgb(62, 62, 62); font-family: "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif; font-size: 16px; line-height: 25.6px; widows: 1; border-style: none none solid; text-align: center; border-bottom-width: 1px; border-bottom-color: rgb(0, 0, 0); box-sizing: border-box !im portant; word-wrap: break-word !im portant; "> there are 35 analgesic drugs in the 2017 edition of the national medical insurance catalog, which are divided into 10 categories, including natural opioids, phenylpiperidine derivatives, morphine derivatives, pyrazolone, acylamine, migraine ergot alkaloids, selective 5-hydroxytryptamine receptor agonists, other opioid salicylic acids and their derivatives, and other antipyretic and analgesic drugs To meet the needs of different pain drugs, opioid receptor agonists / antagonists play an important role On November 11, 2013, the state health and Family Planning Commission, the State Food and Drug Administration and the Ministry of Public Security issued a new catalogue of narcotic drugs, which was officially implemented on January 1, 2014 There are 121 new types of narcotic drugs With the progress of society, in the evolution of narcotics and drugs, medical science has been exploring the characteristics of the effects of this special substance on physiology, spirit and pathology to benefit mankind   none="shifuMouseDownStyle('shifu_bus_002')" style="margin: 1em auto; padding: 0px; max-width: 100%; color: rgb(62, 62, 62); font-family: "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif; font-size: 16px; line-height: 25.6px; widows: 1; border-style: none none solid; text-align: center; border-bottom-width: 1px; Border bottom color: rgb (0, 0, 0); box sizing: border box! 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Im portant; "> Top 10 varieties account for more than 80% of public hospitals in key cities According to the data of the Internet, in 2016, the terminal of analgesic drugs in public hospitals in key cities in China reached 1.958 billion yuan, an increase of 19.82% over the previous year The top 10 varieties are dizosin, oxycodone, propapatamol, aminophenol oxycodone, fentanyl patch, pentazosin, neurotropin, lofendine, tramadol and morphine preparations The top 10 analgesic varieties account for 80.88% of public hospitals in key cities, among which dizosin injection of Yangtze River Pharmaceutical Co., Ltd ranks first, accounting for 42.71%; oxycodone tablets account for 9.44%; propanetamol accounts for 7.74%; paracetamol oxycodone accounts for 4.07%; fentanyl accounts for 3.73%, forming a high product market concentration In 2016, the state strengthened the management of opioid analgesics abuse The data shows that the three terminal pain treatment drug markets in China have reached 22 billion yuan, with a year-on-year growth rate of 6.28% The growth rate has fallen, and the demand is in a slowly rising trend   none="shifuMouseDownStyle('shifu_bus_002')" style="margin: 1em auto; padding: 0px; max-width: 100%; color: rgb(62, 62, 62); font-family: "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif; font-size: 16px; line-height: 25.6px; widows: 1; border-style: none none solid; text-align: center; border-bottom-width: 1px; Border bottom color: rgb (0, 0, 0); box sizing: border box! 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Im portant; "> domestic leading analgesic - dizosin dizosin is a derivative of phenylmorphine, which has the action mechanism of μ - receptor agonist, κ - receptor antagonist, noradrenaline and 5-hydroxytryptamine reuptake inhibitor In 1990, Wyeth was approved by FDA With the merger and reorganization of the global pharmaceutical industry and the transfer of development strategy, Wyeth ceased to sell In 1999, it was listed by Astra company of Sweden under the trade name of dalgan Dizosin is a drug to relieve postoperative pain, body tissue and cancer pain It has the characteristics of pain intensity, efficacy and duration comparable to morphine, so it becomes an alternative drug for morphine, buprenorphine and pethidine It belongs to strong opioid analgesic injection In 2008, China approved the listing of dizosin injection developed and produced by Yangtze River Pharmaceutical Co., Ltd under the trade name of "garonin", which is an exclusive product in China and forms a monopoly position in the domestic market According to data from minenet, in 2016, the sales volume of dizosin, a public hospital in key cities in China, was 837 million yuan, an increase of 25.89% over the previous year Dizosin is a kind of narcotic and analgesic drug widely used in surgery, gynecology and obstetrics It has become the backbone of analgesic drugs in Yangtze River Pharmaceutical industry   none="shifuMouseDownStyle('shifu_bus_002')" style="margin: 1em auto; padding: 0px; max-width: 100%; color: rgb(62, 62, 62); font-family: "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif; font-size: 16px; line-height: 25.6px; widows: 1; border-style: none none solid; text-align: center; border-bottom-width: 1px; Border bottom color: rgb (0, 0, 0); box sizing: border box! 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Im portant; "> the growth rate of patazocin is 76.93% It belongs to opioid receptor agonist / antagonist analgesic It has similar analgesic effect with morphine, dolantin and other opioid drugs Parenteral administration of drugs has a fast and strong analgesic effect, with shorter action time than morphine and dolantin; central inhibition is lighter, especially for respiratory inhibition and nausea and vomiting than opioid drugs; there is no hypotension response; drug dependence is smaller than other similar drugs; it does not affect patients' mood; the drug effect is eliminated rapidly after operation; it can be injected, subcutaneous, intravenous, pumped, etc Three ways of administration According to the data of mienei.com, in 2016, the market of pentazosin, a public hospital in a key city in China, was 65.11 million yuan, an increase of 76.93% over the previous year At present, patazoxin is the exclusive drug sold by CR Shuanghe, and it is a fast-growing variety in recent years   none="shifuMouseDownStyle('shifu_bus_002')" style="margin: 1em auto; padding: 0px; max-width: 100%; color: rgb(62, 62, 62); font-family: "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif; font-size: 16px; line-height: 25.6px; widows: 1; border-style: none none solid; text-align: center; border-bottom-width: 1px; Border bottom color: rgb (0, 0, 0); box sizing: border box! 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Im portant; "> oxycodone, a high growth market, is a semi synthetic pure opioid receptor agonist extracted from the alkaloid thebaine, which has similar potential addiction to morphine In 1995, the FDA approved oxycodone controlled-release tablets for the treatment of moderate and severe pain It is a drug in the catalogue of narcotic drugs issued by the national health and Family Planning Commission, CFDA and the Ministry of public security According to the CFDA website, the registration of oxycodone sustained-release tablets and injections of NAPP pharmaceuticals limited in the UK has been approved, which are registered by hamol limited in the UK and Rafa laboratories in Israel Oxycontin is produced by limited and sold by Mengdi (China) pharmaceutical in subpackage In 2009, oxycodone APIs and tablets of Beijing HuaSu Pharmaceutical Co., Ltd were approved by CFDA for production Oxycodone, as a powerful analgesic, has been used in clinic for nearly one hundred years It is widely used because of its high bioavailability and many ways of administration At present, it is still a variety with large domestic consumption, and also a variety with high growth rate of drug use in domestic hospitals According to the data of minenet, in 2016, the market of oxycodone in public hospitals in key cities in China was 165 million yuan, an increase of 23.05% over the previous year Mainly injection and tablet Oxycodone tablets can be used in the second and third steps of analgesic treatment of moderate and severe pain Moreover, it can be used with a variety of non opioid analgesics and adjuvants to achieve better analgesic effect     none="shifuMouseDownStyle('shifu_bus_002')" style="margin: 1em auto; padding: 0px; max-width: 100%; color: rgb(62, 62, 62); font-family: "Hiragino Sans GB", "Microsoft YaHei", Arial, sans-serif; font-size: 16px; line-height: 25.6px; widows: 1; border-style: none none solid; text-align: center; border-bottom-width: 1px; border-bottom-color: RGB (0,0,0); box sizing: border box! 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Im portant; "> in recent years, the intensive management of tramadol, morphine and dolantin has been constantly changing in the market of mental analgesics in China Tramadol, aminophenol tramadol, fentanyl, morphine and other drugs are growing slowly, and some of them are in a downward trend year by year This is related to the promotion and use of small addictive drugs such as dizosin, pentazosin, oxycodone, paracetamol oxycodone and lofendine The narcotic and analgesic drugs with obvious market decline are morphine preparations Morphine is a three-step analgesic for patients with acute operation, severe trauma and advanced cancer It is also used in non hypertensive myocardial infarction and cardiogenic asthma With the increase of morphine substitutes, morphine has declined steadily According to the data of mienei.com, in 2016, the use of morphine tablets, injections and suppositories in public hospitals in key cities in China was 37.04 million yuan, down 2.76% year on year, and showing a sustained and slow decline trend In addition, tramadol, paracetamol and other varieties are also in the decline of consumption This kind of drugs act on the central nervous system, and the overdose will produce dependence The effects on human body are similar to those of morphine and heroin China controls tramadol and other drugs as psychotropic substances According to the data of mienei.com, in 2016, tramadol, dihydrocodeine aminophenol, tramadol and dolantin were 44.71 million yuan, 17.51 million yuan, 5.87 million yuan and 1.2 million yuan respectively in the public hospitals of key cities in China, down 0.3%, 6.66%, 3.93% and 5.51% year on year respectively In essence, it is necessary to fully understand the needs of cancer pain patients to use psychoanalgesics from the aspect of humanity All in all, the problem of drug abuse has been curbed to some extent, and the initial battle has been won.