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The therapeutic role of pregabalin in chronic pain is receiving increasing attention. What problems should be paid attention to when using the drug?

 Last Update: 2022-10-01
 Source: Internet
 Author: User

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epilepsy awareness

drug induced abnormalities

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Evidence-based medicine, rational use of drugs

Pregabalin is a structural analogue of γ-aminobutyric acid (GABA) that blocks voltage-dependent calcium channels and reduces the release
of neurotransmitters.

The therapeutic role of pregabalin in chronic pain is receiving increasing attention
.

How to stop the drug correctly?

As with all antiepileptic drugs (AEDs), pregabalin is gradually discontinued to minimize the increase in the
frequency of seizures in patients with epilepsy.

Be wary of suicide risk!

Patients taking AED, including pregabalin, for any indication, increase the risk of
suicide in patients.

Patients receiving any AED treatment should take care to monitor for the appearance or worsening of depression, suicidal thoughts or behaviors, and other emotional or behavioral abnormalities
.

Epilepsy and many other diseases that use AED are at increased
risk of suicidal thoughts and behaviors due to the disease itself and morbidity and mortality.

How is drug overdose handled?

In postmarketing experience, the most commonly reported adverse events of overdose of pregabalin included decreased consciousness, depression/anxiety, confusion, agitation, and irritability, as well as seizures and heart block
.

Pregabalin overdose does not have a specific antidote
.

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