The team of Xu Yikai of Nanfang Hospital has published a series of new results in internationally renowned academic journals

Recently, the research results of Professor Xu Yikai's team in the field of tumor molecular imaging and functional imaging of Nanfang Hospital have been published
online in internationally renowned journals such as Advanced Materials, Small and Journal of Controlled Release.

Bidirectional enhancement therapy for immunogenic cell death based on_CaO2@CuS-MnO₂@HA (CCMH) nanocomposites

Inspired by the potential benefits of Ca2+ overload and the logical integration of photodynamic therapy, the study proposes an improved immunotherapy using CaO2@CuS-MnO2@HA nanoparticles (CCMH) bidirectionally enhanced ICD and TAM reset,^Ca2+ overload and_CaO2 triggered by photodynamic therapy Bidirectional enhancement of the ICD of enhanced PDT enables full release
of DAMPs.
At the same time, escaped oxidative damage mitochondrial DNA can also reduce TAM to the M1 phenotype
.
This work provides an attractive option
for immunotherapy targeting primary and distant tumors.
The results were published online in the form of a monograph in Advanced Materials, a top journal in the field of materials, with Huang Cong, a 2019 Ph.
D.
from the Department of Diagnostic Imaging, Nanfang Hospital, as the first author of the paper, Professor Xu Yikai from the Department of Diagnostic Imaging, Professor Zhao Peng from the School of Pharmacy of Southern Medical University and Professor Tao Jia from South China University of Technology as the co-corresponding authors of the paper, and Nanfang Hospital of Southern Medical University as the
first signature.

Cyclotron based on ultra-small magnetic iron oxide nanoparticles accelerates the generation of reactive oxygen species for the treatment of tumor iron death

Inspired by the concept of "cyclotron" in physics, this study proposed a new concept of cyclotron acceleration of ROS generation in tumor cells, and designed and developed a self-assembled nanoparticle (namely SA-SFN-FGNP), which comprehensively utilizes the tumor microenvironment (TME) and endosome acidic conditions, the Fenton reaction, cystine/glutamate reversal transport (System XC-) and GPX4 to accelerate the production of ROS in tumor cells and realize efficient tumor iron death treatment
。 At the same time, SA-SFN-FGNP has a very high longitudinal relaxation rate (r1, 33.
43 mM-1 ^s-1, 3.
0 T), which realizes the MRI visualization
of tumor siderophosis treatment.
The results were published online in the form of a monograph in the top journal in the field of materials, Small (CAS Subclass Region 1), and Professor Xu Yikai and Professor Shen Zheyu (double appointed professors of the department) of the Department of Diagnostic Imaging of Nanfang Hospital are the co-corresponding authors
of the paper.

Rapidly construct 'yolk-shell' structured tumor microenvironment-responsive nanocomposite systems to achieve multi-mode combined sensitization therapy and T1-MR signal enhancement

In this study,a multifunctional_PEGylatedBi2S 3@mBixMnyOz-DOX (PBmB-DOX) nanosystem with a one-step 'yolk-shell' structure
was rapidly formed by using Bi2S₃ nanorods as a partial sacrifice template.
On the one hand, in addition to the controlled release of DOX and the radiotherapy sensitizer Bi₂S₃ nanorod radiotherapy and chemotherapy sensitization effect, the shell structure of the system can be degraded in the tumor microenvironment, and the free Mn ions catalyze the generation of O2 by_H2O2and consume glutathione GSH and a series of reactions.
Improve the hypoxia and high GSH status of tumor area, and enhance the efficacy of
radiotherapy and chemotherapy.
On the other hand, Mn-mediated Fenton-like response and GSH clearance-mediated GPX4 inhibition further played a positive role
in enhancing the effect of radiotherapy and chemotherapy by inducing iron death 。 The results were published online in the form of a monograph in the Journal of Controlled Release, a top journal in the field of medicine, with postdoctoral fellow Hou Meirong and 2018 Ph.
D.
Zhu Kai of the Department of Diagnostic Imaging of Southern Hospital as the co-first authors of the paper, Professor Xu Yikai of the Department of Diagnostic Imaging, Deputy Chief Physician Yan Chenggong and Associate Researcher Zhao Bingxia of the School of Basic Medicine of Southern Medical University as the co-corresponding authors of the paper, and Nanfang Hospital of Southern Medical University as the first signature of the paper
。

In addition, Professor Xu Yikai's team in the Department of Diagnostic Imaging has developed a series of molecular imaging probes
in recent years, focusing on the integration of tumor targeted diagnosis and treatment guided by multimodal imaging.
Since 2022, the team's research results have been published
in J Nanobiotechnology, Nano Research, Bioengineering & Translational Medicine, ACS Applied Materials & Interfaces and other well-known journals.