The team of Professor Rao Zhiming of Jiangnan University published the research results of Bacillus subtilis metabolic engineering to improve riboflavin production by alleviating the limitation of dissolved oxygen

Recently, the team of Professor Rao Zhiming from the School of Bioengineering of Jiangnan University has made important progress in the efficient synthesis of riboflavin.

Riboflavin, also known as microbial B2, is a type of B vitamins and is widely used in the pharmaceutical industry and as a food and feed additive

Rao Zhiming's team first analyzed gene expression changes in the whole genome of Bacillus subtilis under different dissolved oxygen conditions by comparing transcriptomes

Graphical summary

In recent years, under the guidance of the scientific theory of synthetic biology, Professor Rao Zhiming’s team has achieved fruitful results in the systematic construction and industrialization of cell factories for the efficient synthesis of high-value compounds.

Expert introduction

Professor Rao Zhiming

Professor Rao Zhiming, a doctoral supervisor, is currently the deputy dean of the School of Bioengineering of Jiangnan University, formerly the deputy director of the State Key Laboratory of Food Science and Technology and the executive deputy director of the Institute of Food Biotechnology, Jiangsu Institute of Industrial Technology

In recent years, he has undertaken or completed more than 20 projects including national key research and development projects, 863 projects, national fund general projects, 973 sub-projects and enterprise commissioned projects

In the past five years, the corresponding author has published more than 150 papers in authoritative journals including Nature Communications, Science Advances, Advanced Materials, ACS Catalysis, Metabolic Engineering, Green Chemistry, Science of China, Acta Microbiology, Journal of Bioengineering, and Chinese Journal of Chemical Industry.

(This article is reprinted by "Food Science Network", and the article is from Jiangnan University