The team at Southern Medical University developed a non-invasive radiography biomarker for NLR in the tumor immune microenvironment

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Author: Mia

Stomach cancer is one of the most common cancers and the third leading cause

The tumor immune microenvironment (TIME) is increasingly being recognized as a major determinant of tumor biology and a regulator of sensitivity to anti-tumor drugs

However, in recent years, other immune cells, such as neutrophils, can alter the behavior of lymphocytes, thereby regulating tumor progression, and have received more and more attention

On August 30, the Southern Medical University team published a research paper

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Relationship between NLR status and prognosis in TIME

 01 

The research team developed and validated CT-based radiomics scores based on 2272 patients with gastric cancer to study the relationship of radiomic imaging biomarkers to neutrophil-lymphocyte ratio (NLR) in TIME, including its correlation

Kaplan-Meier analyzed disease-free survival (DFS) and overall survival (OS) based on different NLR statuses of gastric cancer patients

Patients in the NLR-Low group had the best prognosis DFS and OS (disease-free survival and overall survival) in the training cohort, internal validation cohort 1, and external validation cohort 1, while patients in the NLR-High group had the worst

Development and validation of biomarkers for radiomics imaging

 02 

The researchers used the Maximum Correlation Minimum Redundancy (mRMR) algorithm to remove redundant features, and then used minimum absolute shrinkage and selection operator regression analysis to select 6 perienceal features and 4 intratumor features to construct predictive radiological imaging biomarkers

Radiomics imaging biomarker performance in training and validation cohorts

The RS of the NLR-High, NLR-Mix, and NLR-Low groups in each queue is significantly different

Prognostic value of biomarkers for radiomics imaging

 03 

Univariate Cox regression analysis showed that radioomic imaging biomarkers were prognostic factors for disease-free survival and overall survival in each cohort

Kaplan-Meier analyzed disease-free survival (DFS) and overall survival (OS) based on different RS groups of patients with

The team assessed the prognostic value

Predictive value of radiomics imaging biomarkers against PD-1 immunotherapy responses

 04 

The study also assessed the association between radiomic imaging biomarkers and anti-PD-1 immunotherapy responses in both cohorts and clinical outcomes

Performance of radiomics imaging biomarkers in evaluating response to anti-PD-1 immunotherapy and clinical outcomes of immunotherapy

Surprisingly, patients with low RS still had the highest OR rates regardless of treatment line, further suggesting that radioomic imaging biomarkers for NLR are associated

Summary of the study

 05 

The study found that radioomic imaging biomarkers of NLR in gastric cancer TIME can be used to assess response to immunotherapy, regardless of treatment
line.

However, due to the limited number of immunotherapy cohorts, future studies of radiomic imaging biomarkers for NLR in TIME should further investigate the relationship between
radiomic imaging biomarkers and immunotherapy responses.

Resources:

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Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for
treatment options.

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