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TERT-BUTYL N-METHYL-N-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDIN-2-YL]CARBAMATE, also known as MK-8628, is a selective inhibitor of the wee1 kinase, which is involved in the regulation of the cell cycle.
It is primarily used in the research and development of new cancer treatments, and is being studied for its potential to treat a wide range of cancers, including leukemias and lymphomas.
The synthesis of TERT-BUTYL N-METHYL-N-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDIN-2-YL]CARBAMATE is a complex process that involves several synthetic routes.
The initial step in the synthesis involves the preparation of the precursor [1,3-dioxabicyclo[6.
1.
0]nonyl]carbamate, which is then transformed into the target compound through a series of other chemical reactions.
One of the most common synthetic routes for TERT-BUTYL N-METHYL-N-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDIN-2-YL]CARBAMATE involves the use of the Strecker reaction, which is a common synthetic method for the preparation of amino acids and other biologically active molecules.
This route begins with the preparation of the precursor [1,3-dioxabicyclo[6.
1.
0]nonyl]carbamate, which is then treated with a variety of chemicals to introduce the necessary functional groups for the synthesis of the target compound.
Another common synthetic route for TERT-BUTYL N-METHYL-N-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDIN-2-YL]CARBAMATE involves the use of a sequence of reactions known as the "household chemical" route.
This route begins with the preparation of the precursor [1,3-dioxabicyclo[6.
1.
0]nonyl]carbamate, which is then treated with a variety of household chemicals, such as sodium hydroxide and hydrochloric acid, to introduce the necessary functional groups for the synthesis of the target compound.
Both of these synthetic routes have their own advantages and disadvantages, and the choice of route depends on the specific goals of the synthesis and the availability of the necessary reagents and equipment.
In addition to these two routes, there are several other synthetic routes for the preparation of TERT-BUTYL N-METHYL-N-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDIN-2-YL]CARBAMATE, each with its own unique characteristics and challenges.
The synthesis of TERT-BUTYL N-METHYL-N-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDIN-2-YL]CARBAMATE is a complex and time-consuming process that requires a high level
