The Synthetic Routes of TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE

TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE is an important intermediate in the synthesis of various chemicals and pharmaceuticals.
This article will discuss some of the commonly used synthetic routes to prepare TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE.

1. Route 1: via N-Formylation of N-(2-Chloroacetamido)-3-Pyrimidinecarboxamide

One of the simplest routes to synthesize TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE involves the N-formylation of N-(2-chloroacetamido)-3-pyrimidinecarboxamide using phosphorus oxychloride and DMF as solvents.
The reaction is exothermic and requires careful handling to avoid any unwanted side reactions.
The product can be purified using column chromatography using a mixture of ethyl acetate and methanol as the eluent.
The yield of the product is typically around 60-70%.

2. Route 2: via 3-Pyrimidinecarboxamide

Another common route to synthesize TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE involves the synthesis of 3-pyrimidinecarboxamide from its precursor N-carboxyanhydride.
The reaction involves the condensation of N-carboxyanhydride with malononitrile in the presence of a catalyst such as cesium carbonate.
The product can be isolated by recrystallization using a suitable solvent such as ethanol or water.
The yield of the product is typically around 70-80%.

3. Route 3: via N-Formylation of N-(2-Chloroacetamido)-3-Pyrimidinecarboxamide Hydrochloride

An alternate route to synthesize TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE involves the N-formylation of N-(2-chloroacetamido)-3-pyrimidinecarboxamide hydrochloride using phosphorus oxychloride and DMF as solvents.
The reaction is exothermic and requires careful handling to avoid any unwanted side reactions.
The product can be purified using column chromatography using a mixture of ethyl acetate and methanol as the eluent.
The yield of the product is typically around 60-70%.

In conclusion, there are several synthetic routes to prepare TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE, each with its own advantages and disadvantages.
The choice of the route depends on the availability of starting materials, the desired yield, and the cost of the reaction.
Regardless of the route chosen, it is essential to follow proper safety protocols and handle the reagents with care to avoid any unwanted side reactions or accidents.