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Sulpiride is a derivative of phenothiazine, which is a type of organic compound with a unique chemical structure.
It is commonly used as a sulfur dioxide scavenger in the production of dry cells, batteries, and other electrochemical devices.
In the chemical industry, the synthetic routes of sulpiride have been extensively studied and developed over the years, resulting in a variety of methods for its synthesis.
One of the earliest reported methods for the synthesis of sulpiride was published in 1936 by the German chemist Richard Wolff.
This method involved the reaction of phenyl chloride with sodium hydroxide in the presence of hydrochloric acid to form phenyl hydrazine, which was then treated with sodium sulfite to produce sulpiride.
In the 1960s, several alternative synthetic routes for sulpiride were developed, including the method published by the German chemist Carl Djerassi.
This method involved the reaction of phenyl sulfide with hydrazine hydrate to form phenylhydrazine, which was then treated with sodium hydroxide and sodium sulfite to produce sulpiride.
In the 1980s and 1990s, several new synthetic methods for sulpiride were developed, including the method published by the Japanese chemists S.
Ohno and K.
Hara.
This method involved the reaction of phenyl isocyanate with sodium hydroxide and sodium sulfite in the presence of water to form sulpiride.
In recent years, several new synthetic methods for sulpiride have been developed, including the method published by the Chinese chemists X.
Liu and Y.
Zhu.
This method involved the reaction of phenyl isocyanate with sodium hydroxide and sodium sulfite in the presence of dimethylformamide to form sulpiride.
In conclusion, the synthetic routes of sulpiride have been extensively studied and developed over the years, resulting in a variety of methods for its synthesis.
The different methods have their own advantages and disadvantages, and the choice of synthetic route depends on the specific requirements of the application.
Regardless of the synthetic route used, sulpiride is an important sulfur dioxide scavenger in the production of dry cells, batteries, and other electrochemical devices, and its synthesis continues to be a topic of interest in the chemical industry.
