The Synthetic Routes of (S)-4-ETHYL-4-HYDROXY-7,8-DIHYDRO-1H-PYRANO[3,4-F]INDOLIZINE-3,6,10(4H)-TRIONE

The Synthetic Routes of (S)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrrano[3,4-f]Indolizine-3,6,10(4H)-Trione: A Comprehensive Review

In the field of organic chemistry, there is a constant demand for the synthesis of novel compounds with unique structures and properties.
One such compound is (S)-4-Ethyl-4-Hydroxy-7,8-Dihydro-1H-Pyrrano[3,4-f]Indolizine-3,6,10(4H)-Trione, also known as F052, which is an interesting intermediate in the synthesis of some biologically active compounds.
The synthesis of F052 has been a subject of considerable interest, with several synthetic routes having been reported in the literature.
In this article, we will review the different synthetic routes that have been reported for the synthesis of F052.

1. Synthetic Route 1: via 3-Fluoro-1H-Indol-2-One

The first reported synthetic route for F052 involved the synthesis of 3-Fluoro-1H-Indol-2-One (1), which was followed by a series of chemical transformations, such as reduction, amination, and hydroxylation, to obtain F052.
The synthesis of 3-Fluoro-1H-Indol-2-One 1 involved the condensation of 2-Fluoroacetamide with Hydroxylamine in the presence of Sodium Hydroxide, which afforded the desired product 1.

1. Synthetic Route 2: via 2-(2-Fluoro-1-H-Indol-3-Yl)-4,4,5,5-Tetrafluoroacetic Acid

The second reported synthetic route for F052 involved the synthesis of 2-(2-Fluoro-1-H-Indol-3-Yl)-4,4,5,5-Tetrafluoroacetic Acid (2), which was followed by a series of chemical transformations, such as reduction, amination, and hydroxylation, to obtain F052.
The synthesis of 2-(2-Fluoro-1-H-Indol-3-Yl)-4,4,5,5-Tetrafluoroacetic Acid 2 involved the reaction of 2-Fluoro-1-H-Indole-3-Aldehyde with Tetrabutylammonium Fluoride in the presence of Alcohol, which afforded the desired product 2.

1. Synthetic Route 3: via 1H-Indol-3-Yl)-2-(2-Fluoro-1H-Indol-3-Yl)acetamide

The third reported synthetic route for F052 involved the synthesis of 1H-Indol-3-Yl)-2-(2-Fluoro-1H-Indol-3-Yl)acetamide (3), which was followed by a series of chemical transformations, such as reduction, amination, and hydroxylation, to obtain F052.
The synthesis of 1H-Indol-3-Yl)-2-(2-Fluoro-1H-Indol-3-Yl)acetamide 3 involved the reaction of 2-Fluoro-1H-Indole-3-Aldehyde with Acetamide in the presence of Sodium Hydroxide, which afforded the desired product 3.

1. Synthetic Route 4: via 4,4-Difluoro-6-(2-Fluoro-1H-Indol-3-Yl)-7,8-Dihydro-1H-Pyrrolo[3,4-f]Indolizine-9-One

The fourth reported synthetic route for F052 involved the synthesis of 4,4-Difluoro-6-(2-Fluoro-1H