The Synthetic Routes of Rivastigmine tartrate

Rivastigmine tartrate is a cholinesterase inhibitor that is commonly used to treat Alzheimer's disease and other dementia-related disorders.
The synthesis of rivastigmine tartrate has been documented in several literature reports, but the synthetic routes vary depending on the starting materials and the desired product.
In this article, we will discuss some of the commonly used synthetic routes for the preparation of rivastigmine tartrate.

1. Synthesis via N-[2-(dimethylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide

This route involves the synthesis of the intermediate N-[2-(dimethylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide, which is then hydrolyzed to form rivastigmine tartrate.
The synthesis of N-[2-(dimethylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide can be achieved by following a series of steps, including the synthesis of 2,3-dihydro-1H-indole-4-carboxylic acid, its condensation with dimethylamine, and the final condensation with acetamide.
This route is reported to yield a crude product that requires further purification to obtain a pure sample of N-[2-(dimethylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide.

1. Synthesis via N-[2-(diethylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide

This route is similar to the previous one, but involves the use of diethylamine instead of dimethylamine.
The synthesis of N-[2-(diethylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide can be achieved by following a series of steps, including the synthesis of 2,3-dihydro-1H-indole-4-carboxylic acid, its condensation with diethylamine, and the final condensation with acetamide.
This route is also reported to yield a crude product that requires further purification to obtain a pure sample of N-[2-(diethylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide.

1. Synthesis via N-[2-(dibutylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide

This route involves the synthesis of the intermediate N-[2-(dibutylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide, which is then hydrolyzed to form rivastigmine tartrate.
The synthesis of N-[2-(dibutylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide can be achieved by following a series of steps, including the synthesis of 2,3-dihydro-1H-indole-4-carboxylic acid, its condensation with dibutylamine, and the final condensation with acetamide.
This route is reported to yield a crude product that requires further purification to obtain a pure sample of N-[2-(dibutylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide.

1. Synthesis via N-[2-(dibenzylamino)ethyl]-N-(2,3-dihydro-1H-indol-4-yl)-acetamide

This route involves the synthesis of the intermediate N-[2-(d