The Synthetic Routes of Quinolinium, 2-methyl-1-(3-sulfopropyl)-, inner salt

Quinolinium, 2-methyl-1-(3-sulfopropyl)-, inner salt, also known as 2-methyl-1H-quinolin-3-ium-3-sulfonate, is a synthetic compound that is commonly used in various industrial applications such as in the production of pharmaceuticals, agrochemicals, and dyes.
This compound is synthesized through several synthetic routes, which can be broadly classified into three categories - direct synthesis, indirect synthesis, and substitution reactions.

Direct Synthesis Route:
The direct synthesis route involves the reaction of 2-methylquinoline with 3-sulfopropylamine in the presence of a strong base such as sodium hydride.
The reaction produces the desired inner salt of quinolinium in good yield.
This route is relatively simple and straightforward, but it requires the use of expensive and hazardous reagents such as sodium hydride.

Indirect Synthesis Route:
The indirect synthesis route involves the synthesis of 3-sulfopropylamine, which is then reacted with 2-methylquinoline to produce the desired inner salt of quinolinium.
3-sulfopropylamine can be synthesized by the reaction of sodium sulfite with dimethylformamide or by the reduction of 3-sulfopropyl dichloride.
The indirect synthesis route is more economical and safer than the direct route, as it does not require the use of hazardous reagents.

Substitution Reactions:
The substitution reaction route involves the replacement of the functional groups in 2-methylquinoline with the functional groups present in 3-sulfopropylamine.
This route is versatile and allows for the synthesis of a variety of quinolinium derivatives with different functional groups.
The substitution reaction can be carried out by using different reagents such as hydrochloric acid, hydroiodic acid, and other strong acids.

In conclusion, the synthesis of quinolinium, 2-methyl-1-(3-sulfopropyl)-, inner salt can be achieved through various synthetic routes, each with its own advantages and disadvantages.
The direct synthesis route is relatively simple but requires the use of expensive and hazardous reagents.
The indirect synthesis route is more economical and safer, and the substitution reaction route allows for the synthesis of a variety of quinolinium derivatives with different functional groups.
The selection of the synthesis route depends on the intended application, the availability of reagents, and the safety considerations.