The Synthetic Routes of Pyrimidine, 2-chloro-5-fluoro-4-methyl- (9CI)

The synthesis of pyrimidine, a important organic compound used in the production of various pharmaceuticals, is an important process in the chemical industry.
One of the commonly used methods for the synthesis of pyrimidine is the synthetic route of 2-chloro-5-fluoro-4-methyl- (9CI).
This route involves a series of chemical reactions that convert simple starting materials into the desired product.

The synthetic route of 2-chloro-5-fluoro-4-methyl- (9CI) begins with the reaction of 2-fluoro-5-methylthiophenone with chloroform under the presence of an acid catalyst.
This reaction is known as the Cannizzaro reaction and it forms the intermediate 2-chloro-5-fluoro-3-methylthiophenone.

The next step in the synthetic route is the reaction of the intermediate 2-chloro-5-fluoro-3-methylthiophenone with sodium hydroxide to form the corresponding sodium salt.
This salt is then treated with chloroform and an excess of hydrogen chloride to form the desired product 2-chloro-5-fluoro-4-methyl- (9CI).

Another synthetic route for the synthesis of pyrimidine is the synthesis of pyrimidine-5-one by the reaction of urea with formaldehyde in the presence of an acid catalyst.
This reaction forms the intermediate pyrimidine-5-one, which can then be converted into the desired product 2-chloro-5-fluoro-4-methyl- (9CI) by a series of chemical reactions.

The production of 2-chloro-5-fluoro-4-methyl- (9CI) is an important step in the production of various pharmaceuticals such as anti-cancer drugs, antiviral drugs and anti-inflammatory drugs.
The compound is also widely used in research and development for the synthesis of new pharmaceuticals and other chemicals.

One of the advantages of the synthetic route of 2-chloro-5-fluoro-4-methyl- (9CI) is that it uses easily available starting materials, such as 2-fluoro-5-methylthiophenone and chloroform, and it is relatively simple and efficient.
This means that the production costs of the compound are relatively low, making it an attractive option for large scale production.

However, the synthetic route of 2-chloro-5-fluoro-4-methyl- (9CI) also has some disadvantages.
For example, the reaction mixture may contain a significant amount of hydrogen chloride which can be dangerous and it is also corrosive.
Therefore, special precautions must be taken when handling this compound.

Overall, the synthetic route of 2-chloro-5-fluoro-4-methyl- (9CI) is an important process in the chemical industry and is widely used in the production of various pharmaceuticals.
It is relatively simple and efficient and the production costs are relatively low.
However, special precautions must be taken when handling this compound due to its corrosive and dangerous nature.