The Synthetic Routes of Pelitinib

Pelitinib is a novel and highly potent tyrosine kinase inhibitor that has shown promising results in the treatment of various types of cancer.
The synthesis of Pelitinib has been described in several research articles, with different synthetic routes being proposed.
In this article, we will discuss some of the most commonly used synthetic routes for Pelitinib and their advantages and disadvantages.

One of the most commonly used synthetic routes for Pelitinib is through a combination of two different synthetic methods, namely the Suzuki-Miyaura coupling reaction and the Stille coupling reaction.
In this route, a starting material known as (S)-2-(4-nitrophenyl)-propionamide is used, which is first synthesized through a series of chemical reactions.
This starting material is then coupled with various aryl iodides using the Suzuki-Miyaura and Stille coupling reactions to form a series of intermediate compounds.
These intermediate compounds are then further transformed into Pelitinib through a set of chemical reactions that involve the introduction of various functional groups.

Another synthetic route for Pelitinib involves the use of the C-H activation method, which involves the use of palladium catalysts to activate the C-H bonds of various starting materials.
This method involves the use of several chemical reagents and catalysts, and can be divided into several steps, including the preparation of the starting materials, the activation of the C-H bonds, and the formation of the final product.
One of the advantages of this method is that it allows for the formation of multiple bonds in a single step, leading to a more efficient synthesis process.

A third synthetic route for Pelitinib involves the use of the Ullmann condensation reaction, which involves the condensation of various starting materials containing an amine group and an acid halide group.
This method involves the use of several chemical reagents and catalysts, and can be divided into several steps, including the preparation of the starting materials, the condensation reaction, and the formation of the final product.
One of the advantages of this method is that it allows for the formation of a variety of functional groups in the final product, which can be further modified to form Pelitinib.

In conclusion, there are several synthetic routes for Pelitinib that have been proposed in the literature, each with its own advantages and disadvantages.
The choice of synthetic route depends on the specific properties of the starting materials and the desired properties of the final product.
The C-H activation method, the Suzuki-Miyaura and Stille coupling reactions, and the Ullmann condensation reaction are some of the commonly used synthetic routes for Pelitinib.
However, further research is needed to optimize these routes and to develop new synthetic methods for Pelitinib.