The Synthetic Routes of Oxaliplatin

Oxaliplatin is a chemotherapy drug that is primarily used to treat colorectal cancer.
It is a platinum-based drug that is synthesized through several synthetic routes.
In this article, we will discuss the various synthetic routes of oxaliplatin and their advantages and disadvantages.

The most common synthetic route for oxaliplatin involves the reduction of chloro(cyclohexylamino)platinum(II) with sodium borohydride in the presence of a solvent such as dimethylformamide or dimethylacetamide.
This route is simple, efficient, andcost-effective.
However, it requires the use of toxic reagents such as hydrogen chloride and sodium borohydride, which can pose a health risk to the synthetic chemists.

Another synthetic route for oxaliplatin involves the reduction of (thiourea-O-benzene)platinum(II) with lithium aluminum hydride in the presence of a solvent such as dichloromethane.
This route is also efficient and cost-effective, and it does not require the use of toxic reagents.
However, it can produce unwanted side products that may compromise the purity of the final product.

A recent synthetic route for oxaliplatin involves the use of microwave-assisted hydrothermal synthesis.
This route involves the reaction of chloro(methylamino)platinum(II) with sodium borohydride in the presence of a microwave solvent such as sodium carbonate.
This route is more rapid and efficient than traditional synthetic routes, and it does not require the use of toxic reagents.
However, it may require the use of expensive equipment such as a microwave reactor.

Another synthetic route for oxaliplatin involves the reduction of chloro(methylamino)platinum(II) with lithium aluminum hydride in the presence of a solvent such as 1,4-dioxane.
This route is also efficient and cost-effective, and it does not require the use of toxic reagents.
However, it may produce unwanted side products that can compromise the purity of the final product.

In conclusion, there are several synthetic routes for oxaliplatin, each with its own advantages and disadvantages.
The most common route involves the reduction of chloro(cyclohexylamino)platinum(II) with sodium borohydride in the presence of a solvent such as dimethylformamide or dimethylacetamide.
This route is simple, efficient, and cost-effective.
However, it requires the use of toxic reagents, which can pose a health risk to the synthetic chemists.
Other routes, such as microwave-assisted hydrothermal synthesis and reduction of chloro(methylamino)platinum(II) with lithium aluminum hydride, are more rapid and efficient but may require the use of expensive equipment or produce unwanted side products.
Ultimately, the choice of synthetic route will depend on the specific needs and resources of the synthetic chemists.