-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Nortriptyline hydrochloride is a tricyclic antidepressant drug that is used to treat a variety of mental health conditions, including depression and anxiety disorders.
It is synthesized through several synthetic routes, which can be broadly classified into three categories: classical synthesis, modern synthesis, and total synthesis.
In this article, we will discuss the synthetic routes of nortriptyline hydrochloride in detail.
Classical Synthesis of Nortriptyline Hydrochloride
Classical synthesis refers to the synthesis of chemicals through time-tested methods that have been developed over many years.
The classical synthesis of nortriptyline hydrochloride involves several steps, including the synthesis of anthranilic acid, which is an intermediate in the synthesis of nortriptyline.
The synthesis of anthranilic acid involves the reaction of chloroform with o-toluidine in the presence of sodium hydroxide.
This reaction is followed by the hydrolysis of the resulting chloride to obtain anthranilic acid.
The synthesis of nortriptyline hydrochloride involves the reaction of anthranilic acid with a variety of reagents, including chloral hydrate, ethanol, and hydrochloric acid.
This leads to the formation of nortriptyline hydrochloride, which is the final product.
Modern Synthesis of Nortriptyline Hydrochloride
Modern synthesis refers to the synthesis of chemicals through newer methods that have been developed in recent years.
The modern synthesis of nortriptyline hydrochloride involves several steps, including the synthesis of anthranilic acid, which is an intermediate in the synthesis of nortriptyline.
The synthesis of anthranilic acid involves the reaction of 2-aminotoluene with chloroform in the presence of a catalyst, such as sodium hydroxide.
This reaction leads to the formation of anthranilic acid, which is then used in the next step of the synthesis.
The synthesis of nortriptyline hydrochloride involves the reaction of anthranilic acid with a variety of reagents, including chloral hydrate
