The Synthetic Routes of N,N'-Bis (4-Ethoxycarboxylphenyl) -N-Benzylformamidi

The synthesis of N,N'-Bis (4-Ethoxycarboxylphenyl) -N-Benzylformamidi is a complex process that involves several steps.
This compound is commonly used as a building block for the synthesis of other molecules in the pharmaceutical and chemical industries.

One of the most common synthetic routes for N,N'-Bis (4-Ethoxycarboxylphenyl) -N-Benzylformamidi is through a sequence of reactions known as the "Corey-Kim-Schreiber" (CKS) reaction.
This reaction involves the nucleophilic substitution of a phenoxide with an amide in the presence of a Bronsted acid catalyst.
The reaction starts with the preparation of a phenoxide derivative, which is then treated with benzylformamide and a catalytic amount of H+.
The resulting product is then hydrolyzed to yield N,N'-Bis (4-Ethoxycarboxylphenyl) -N-Benzylformamidi.

Another synthetic route for N,N'-Bis (4-Ethoxycarboxylphenyl) -N-Benzylformamidi is through the "Ullmann" reaction.
This reaction involves the condensation of a phenol with a substituted acetylene in the presence of a Lewis acid catalyst.
The reaction is then followed by a hydrolysis step to remove the protecting group.
This route is considered to be more efficient and convenient than the CKS route, as it allows for the simultaneous formation of the N-benzyl group and the N,N'-bis (4-ethoxycarboxylphenyl) moiety.

In addition to the above-mentioned synthetic routes, N,N'-Bis (4-Ethoxycarboxylphenyl) -N-Benzylformamidi can also be synthesized through a combination of chemical reactions such as alkylation, halogenation, and oxidation.

Overall, the synthesis of N,N'-Bis (4-Ethoxycarboxylphenyl) -N-Benzylformamidi can be achieved through various synthetic routes, each with its own advantages and disadvantages.
The choice of synthetic route depends on the availability of starting materials, the scale of production, and the desired product purity.
Regardless of the route chosen, the synthesis of N,N'-Bis (4-Ethoxycarboxylphenyl) -N-Benzylformamidi is a complex process that requires a thorough understanding of organic chemistry and the use of specialized equipment and reagents.