The Synthetic Routes of N′-(4-Ethoxycarbonylphenyl)-N-methyl-N-phenylformamidine

N'-(4-Ethoxycarbonylphenyl)-N-methyl-N-phenylformamidine, commonly referred to as PCMO, is a synthetic chemical compound that has gained significant attention in the chemical industry due to its unique properties and versatile applications.
The compound is often used as a building block for the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals.

The synthesis of PCMO can be achieved through several different routes, each with its own advantages and disadvantages.
In this article, we will discuss the most commonly used synthetic routes for PCMO and their applications in the chemical industry.

Route 1: Via N-Boc-N-Me-N-Ph-Formamide

This route involves the synthesis of N-Boc-N-Me-N-Ph-Formamide, which is then hydrolyzed to form PCMO.
The synthesis of N-Boc-N-Me-N-Ph-Formamide typically involves the reaction of N-Boc-N-Me-N-Ph-Acetamide with HCl, followed by hydrolysis using NaOH.

This route is relatively simple and can be easily scaled up for industrial production.
However, it requires the use of hazardous chemicals such as HCl and NaOH, and the hydrolysis step can be complicated and time-consuming.

Route 2: Via N-Me-N-Ph-Formamide-Phenyl-Acetamide

This route involves the synthesis of N-Me-N-Ph-Formamide-Phenyl-Acetamide, which is then hydrolyzed to form PCMO.
The synthesis of N-Me-N-Ph-Formamide-Phenyl-Acetamide typically involves the reaction of N-Me-N-Ph-Formamide with Phenyl Acetyl Chloride, followed by hydrolysis using NaOH.

This route is similar to the previous one, but it does not require the use of HCl, making it safer and more convenient.
However, it also requires the use of NaOH for hydrolysis, which can be problematic.

Route 3: Via N-Me-N-Ph-Formamide-Phenyl-Formamide

This route involves the synthesis of N-Me-N-Ph-Formamide-Phenyl-Formamide, which is then hydrolyzed to form PCMO.
The synthesis of N-Me-N-Ph-Formamide-Phenyl-Formamide typically involves the reaction of N-Me-N-Ph-Formamide with Phenyl Isocyanate, followed by hydrolysis using NaOH.

This route is similar to the previous two, but it involves the reaction of N-Me-N-Ph-Formamide with Phenyl Isocyanate, which can be more reactive and easier to handle than NaOH.
However, this route also requires the use of NaOH for hydrolysis.

In conclusion, there are several synthetic routes for PCMO available in the chemical industry.
Each route has its own advantages and disadvantages, and the choice of route depends on the specific application and production scale.
It is essential to consider the cost, safety, and efficiency of the synthetic route when selecting the appropriate one for a particular application.