The Synthetic Routes of N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide

N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide is an important intermediate in the production of various chemicals and pharmaceuticals.
The synthesis of this compound involves several steps, which can be classified into natural and synthetic routes.
In this article, we will discuss the synthetic routes of N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide.

Synthetic routes are an approach to synthesize a compound that involves the use of synthetic methods.
These methods can include chemical reactions, chemical transformations, or a combination of both.
In the case of N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide, there are several synthetic routes that can be used.

The first synthetic route is through the reaction of 2,4-dimethylphenyl bromide with benzene sulfonamide.
This reaction involves the formation of an intermediate biphenyl amide, which is then treated with sulfuric acid to form the desired product.
This route is shown below:

2,4-dimethylphenyl bromide + benzene sulfonamide → biphenyl amide + H2SO4 → N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide

The second synthetic route is through the reaction of 2,4-dimethylphenyl bromide with 2-aminobenzenesulfonyl chloride.
This reaction is a two-step process that involves the formation of an intermediate amide and the subsequent treatment with HCl to form the desired product.
This route is shown below:

2,4-dimethylphenyl bromide + 2-aminobenzenesulfonyl chloride → amide + HCl → N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide

The third synthetic route is through the reaction of 2,4-dimethylphenyl bromide with phenylbenzene sulfonamide.
This reaction is a four-step process that involves the formation of an intermediate sulfonamide, the treatment with sodium hydroxide and sodium bicarbonate, and finally the formation of the desired product.
This route is shown below:

2,4-dimethylphenyl bromide + phenylbenzene sulfonamide → sulfonamide + NaOH + NaHCO3 → N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide

The fourth synthetic route is through the reaction of 2,4-dimethylphenyl bromide with para-nitrophenylbenzene sulfonamide.
This reaction involves the formation of an intermediate nitroso compound, which is then treated with sodium hydroxide and sodium bicarbonate to form the desired product.
This route is shown below:

2,4-dimethylphenyl bromide + para-nitrophenylbenzene sulfonamide → nitroso compound + NaOH + NaHCO3 → N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide

In conclusion, the synthetic routes of N-(2,4-Dimethylphenyl) 2-bromobenzenesulfonamide involve several steps and different reagents.
The selection of a particular route depends on factors such as cost, availability of reagents, and the scale of production.
These synthetic routes provide a valuable contribution to the chemical industry and have applications in the production of various chemicals and pharmaceuticals.