The Synthetic Routes of methyl N'-nitrocarbamimidate

Methyl N'-nitrocarbamimidate is a synthetic chemical compound that is commonly used in the pharmaceutical, agrochemical, and chemical industries.
It is used as a reagent for the synthesis of other chemicals and as an intermediates for the production of various products.
In this article, we will focus on the synthetic routes of methyl N'-nitrocarbamimidate, which can be broadly classified into two categories: direct and indirect routes.

Direct Route

The direct route to synthesize methyl N'-nitrocarbamimidate involves the use of nitration and amidation reactions.
The nitration reaction involves the addition of nitric acid to methyl amine to form methyl nitrate.
The amidation reaction involves the reaction of the methyl nitrate with carbamic acid to form methyl N'-nitrocarbamimidate.
The reaction is typically carried out in the presence of a solvent such as acetonitrile or DMF, and a catalyst such as hydrochloric acid or sulfuric acid.
The yield of the reaction can be improved by using a high concentration of nitric acid and by maintaining the reaction mixture at a low temperature.

Indirect Route

The indirect route to synthesize methyl N'-nitrocarbamimidate involves the use of a intermediate called N-(2-chloroethyl)nitroguanidine.
The synthesis of N-(2-chloroethyl)nitroguanidine involves the reaction of 2-chloroethyl amine with nitric acid to form N-(2-chloroethyl)nitrate, followed by the reaction of the nitrate with guanidine to form N-(2-chloroethyl)nitroguanidine.
The reaction is typically carried out in the presence of a solvent such as acetic acid or water, and a catalyst such as hydrochloric acid or sodium hydroxide.
The yield of the reaction can be improved by using a high concentration of nitric acid and by maintaining the reaction mixture at a low temperature.

The synthesis of methyl N'-nitrocarbamimidate using N-(2-chloroethyl)nitroguanidine as an intermediate involves the reaction of N-(2-chloroethyl)nitroguanidine with methyl amine to form N-(2-chloroethyl)methylamine.
The methylation reaction is typically carried out in the presence of a solvent such as DMF or acetonitrile, and a catalyst such as pyridine or collidine.
The yield of the reaction