-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Methyl 3-bromothiophene-2-carboxylate is an important intermediate in the chemical industry and has numerous applications in the production of various chemicals, drugs, and materials.
The synthetic routes for this compound can vary depending on the starting materials and the desired product.
One of the most common synthetic routes for methyl 3-bromothiophene-2-carboxylate involves the reaction of 2-bromothiophene-3-carboxylic acid with methyl iodide in the presence of a solvent such as DMF or DMA.
The reaction proceeds through a SN2 mechanism and results in the formation of the desired carboxylate.
This route is widely used due to the availability of 2-bromothiophene-3-carboxylic acid, which can be easily synthesized from 2-bromothiophene using known synthetic methods.
Another synthetic route for methyl 3-bromothiophene-2-carboxylate involves the reaction of 2-bromothiophene with methyl 3-bromopropionate in the presence of a Lewis acid catalyst such as AlCl3.
The reaction proceeds through an electrophilic substitution mechanism and also results in the formation of the desired carboxylate.
This route is also commonly used due to the availability of methyl 3-bromopropionate, which can be easily synthesized from 3-bromopropionic acid using known synthetic methods.
A third synthetic route for methyl 3-bromothiophene-2-carboxylate involves the reaction of 2-bromothiophene with methyl iodide in the presence of a strong base such as sodium hydroxide.
The reaction proceeds through a SN2 mechanism and results in the formation of the desired carboxylate.
This route is less commonly used due to the harsh conditions required for the reaction.
Overall, the synthetic routes for methyl 3-bromothiophene-2-carboxylate vary depending on the starting materials and the desired product.
The most commonly used routes involve the reaction of 2-bromothiophene-3-carboxylic acid with methyl iodide or the reaction of 2-bromothiophene with methyl 3-bromopropionate in the presence of a Lewis acid catalyst.
These routes are widely used in the chemical industry and are important for the production of various chemicals, drugs, and materials.
