The Synthetic Routes of Methyl 2-(trifluoromethyl)nicotinate

Methyl 2-(trifluoromethyl)nicotinate is a prominent organic compound that is widely used as an intermediate in the production of various chemicals, pharmaceuticals, and agrochemicals.
This compound is synthesized through several chemical routes in the chemical industry.
In this article, we will discuss some of the most commonly used synthetic routes for the preparation of methyl 2-(trifluoromethyl)nicotinate in the chemical industry.

1. The P2P route

The P2P (Purification by Phosphorylation) route is one of the most common methods used for the industrial-scale production of methyl 2-(trifluoromethyl)nicotinate.
This route involves several steps, including the synthesis of 2-bromo-1,3-propanediol, which is then converted to 2-(trifluoromethyl)nicotinic acid through a series of chemical reactions.
The final step in this route involves the esterification of 2-(trifluoromethyl)nicotinic acid with methanol to yield methyl 2-(trifluoromethyl)nicotinate.

2. The Citric Acid route

The Citric Acid route is another commonly used method for the synthesis of methyl 2-(trifluoromethyl)nicotinate.
This route involves the conversion of 2-bromo-1,3-propanediol to 2-(trifluoromethyl)nicotinic acid through several chemical reactions.
The final step in this route involves the esterification of 2-(trifluoromethyl)nicotinic acid with methanol in the presence of citric acid as a catalyst to yield methyl 2-(trifluoromethyl)nicotinate.

3. The Tishchenko reaction

The Tishchenko reaction is a widely used chemical reaction in organic synthesis that involves the reaction of an α-halogenated carboxylic acid with an aromatic amine in the presence of a strong acid catalyst to yield an arylamide.
This reaction can be used for the synthesis of methyl 2-(trifluoromethyl)nicotinate by using 2-bromo-1,3-propanediol as the α-halogenated carboxylic acid and aniline as the aromatic amine.
The reaction is typically carried out in the presence of a strong acid such as sulfuric acid to yield methyl 2-(trifluoromethyl)nicotinate.

4. The Moffat reaction

The Moffat reaction is another widely used chemical reaction in organic synthesis that involves the reaction of a secondary or tertiary amine with an α-halogenated carboxylic acid in the presence of a strong acid catalyst to yield an arylamide.
This reaction can be used for the synthesis of methyl 2-(trifluoromethyl)nicotinate by using 2-bromo-1,3-propanediol as the α-halogenated carboxylic acid and aniline or another suitable amine as the reactant.
The reaction typically involves the use of a strong acid such as sulfuric acid to yield methyl 2-(trifluoromethyl)nicotinate.

In conclusion, methyl 2-(trifluoromethyl)nicotinate is an important organic compound that is widely used as an intermediate in the production of various chemicals, pharmaceuticals, and agrochemicals.
Several synthetic routes are available for the industrial-scale production of methyl 2-(trifluoromethyl)nicotinate, including the P2P route, the Citric Acid route, the Tishchenko reaction,