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The Synthetic Routes of Methyl 1-(2,3-dihydroxypropyl)-1,4-dihydro-4-oxo-3-(phenylmethoxy)-2-pyridinecarboxylate: A Comprehensive Review
Introduction:
Methyl 1-(2,3-dihydroxypropyl)-1,4-dihydro-4-oxo-3-(phenylmethoxy)-2-pyridinecarboxylate is an organic compound with a complex chemical structure.
This compound has gained significant interest in the chemical industry due to its potential applications in various fields, including pharmaceuticals, agrochemicals, and cosmeceuticals.
In this article, we will discuss the synthetic routes of methyl 1-(2,3-dihydroxypropyl)-1,4-dihydro-4-oxo-3-(phenylmethoxy)-2-pyridinecarboxylate and the methods used to synthesize this compound.
Synthetic Routes:
There are several synthetic routes available for the synthesis of methyl 1-(2,3-dihydroxypropyl)-1,4-dihydro-4-oxo-3-(phenylmethoxy)-2-pyridinecarboxylate.
Some of the commonly used methods are explained below:
- Hydrolysis of N-[(2,3-Dihydro-1H-benzoxazepin-9-yl)(methyl)amino]-3-phenylpropanamide:
This is a multi-step synthetic route that involves the synthesis of N-[(2,3-Dihydro-1H-benzoxazepin-9-yl)(methyl)amino]-3-phenylpropanamide, which is then hydrolyzed to obtain methyl 1-(2,3-dihydroxypropyl)-1,4-dihydro-4-oxo-3-(phenylmethoxy)-2-pyridinecarboxylate.
- Direct Synthesis:
This is a one-step synthetic route that involves the reaction of 2-[(3-phenylpropyl)amino]-4-oxo-4H-3,1-benzoxazepine-9-carboxylic acid with methyl 2-[(3-hydroxylpropyl)amino]-4-oxo-4H-3,1-benzoxazepine-9-carboxylic acid to obtain methyl 1-(2,3-dihydroxypropyl)-1,4-dihydro-4-oxo-3-(phenylmethoxy)-2-pyridinecarboxylate.
- Reductive Amination:
This is a two-step synthetic route that involves the synthesis of N-[(2,3-dihydro-1H-benzoxazepin-9-yl)(methyl)amino]-3-phenylpropanamide followed by its reduction to obtain methyl 1-(2,3-dihydroxypropyl)-1,4-dihydro-4-oxo-3-(phenylmethoxy)-2-pyridinecarboxylate.
- Direct Reduction:
This is a one-step synthetic route that involves the reduction of N-[(2,3-dihydro-1H-benzoxazepin-9-yl)(methyl)amino]-3-phenylpropanamide with hydrogen gas to obtain methyl 1-(2,3-dihydroxypropyl)-1,4-dihydro-4-oxo-3-(phenylmeth
