The Synthetic Routes of Itopride hydrochloride

Itopride hydrochloride is a synthetic organic compound that is used as a pharmaceutical drug for the treatment of various gastrointestinal disorders.
The synthesis of Itopride hydrochloride can be achieved through several synthetic routes, each of which has its own advantages and disadvantages.
In this article, we will discuss some of the commonly used synthetic routes for the preparation of Itopride hydrochloride.

Route 1: Des-N-Methyltriptamine hydrochloride-1,2-diamine synthesis route

This route involves the synthesis of des-N-methyltriptamine hydrochloride, followed by its coupling with hydrochloric acid.
The synthesis of des-N-methyltriptamine hydrochloride can be achieved through several methods, including the reduction of N-methyl-1H-indole-3-amine with lithium aluminum hydride or the synthesis of N-methyl-3-triptamine with subsequent reduction with hydrogen in the presence of palladium on barium sulfate.
The coupling of des-N-methyltriptamine hydrochloride with hydrochloric acid can be carried out using conventional hydrochlorination reactions, such as the reaction with HCl gas or the reaction with HCl solution in the presence of a catalyst such as pyridine.

Route 2: N-Methyl-1,2,3-triptamine synthesis route

This route involves the synthesis of N-methyl-1,2,3-triptamine, followed by its conversion to Itopride hydrochloride.
The synthesis of N-methyl-1,2,3-triptamine can be achieved through several methods, including the synthesis of N-methyl-3-triptamine with subsequent reduction with hydrogen in the presence of palladium on barium sulfate, or the synthesis of N-methyl-1,2-diamine with subsequent reduction with hydrogen in the presence of palladium on barium sulfate.
The conversion of N-methyl-1,2,3-triptamine to Itopride hydrochloride can be achieved using conventional hydrochlorination reactions, such as the reaction with HCl gas or the reaction with HCl solution in the presence of a catalyst such as pyridine.

Route 3: N-Methyl-3-triptamine synthesis route

This route involves the synthesis of N-methyl-3-triptamine, followed by its conversion to Itopride hydrochloride.
The synthesis of N-methyl-3-triptamine can be achieved through several methods, including the reduction of N-methyl-1H-indole-3-amine with lithium aluminum hydride or the synthesis of N-methyl-3-triptamine with subsequent reduction with hydrogen in the presence of palladium on barium sulfate.
The conversion of N-methyl-3-triptamine to Itopride hydrochloride can be achieved using conventional hydrochlorination reactions, such as the reaction with HCl gas or the reaction with HCl solution in the presence of a catalyst such as pyridine.

Route 4: N-(1,2-Dihydro-3-oxo-6-aza-benz[f]indole-2-ylidene)methanamine synthesis route

This route involves the synthesis of N-(1,2-dihydro-3-oxo-6-aza-benz[f]indole-2-ylidene)methanamine, followed by its conversion to Itopride hydrochloride.
The synthesis of N-(1,2-dihydro-3